Improved Detection of Molecular Markers of Atherosclerotic Plaques Using Sub-Millimeter PET Imaging.
Animals
Antibodies
/ administration & dosage
Biomarkers
/ metabolism
Disease Models, Animal
Fluorine Radioisotopes
/ chemistry
Humans
Injections
Mice
Molecular Imaging
Plaque, Atherosclerotic
/ diagnostic imaging
Positron Emission Tomography Computed Tomography
/ methods
Radiopharmaceuticals
/ chemistry
Tissue Distribution
Vascular Cell Adhesion Molecule-1
/ metabolism
AlF-radiolabelling
PET imaging
molecular imaging
nanobody
single-domain antibody
sub-millimetre resolution
vulnerable plaque
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 Apr 2020
16 Apr 2020
Historique:
received:
30
03
2020
revised:
13
04
2020
accepted:
13
04
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
26
1
2021
Statut:
epublish
Résumé
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution. This study aimed to assess the targeting and biodistribution of a novel fluorine-18 anti-VCAM-1 Nanobody (Nb), and to investigate whether sub-millimetre resolution PET imaging could improve detectability of plaques in mice. The anti-VCAM-1 Nb functionalised with the novel restrained complexing agent (RESCA) chelator was labelled with [
Identifiants
pubmed: 32316285
pii: molecules25081838
doi: 10.3390/molecules25081838
pmc: PMC7221983
pii:
doi:
Substances chimiques
Antibodies
0
Biomarkers
0
Fluorine Radioisotopes
0
Radiopharmaceuticals
0
Vascular Cell Adhesion Molecule-1
0
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 675417 PET3D
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G005815N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G0D8817N
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