X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4
CD4-Positive T-Lymphocytes
/ immunology
Gene Expression Regulation, Viral
Gene Knockdown Techniques
HIV Infections
/ immunology
HIV Long Terminal Repeat
HIV-1
/ physiology
Heterogeneous-Nuclear Ribonucleoproteins
/ chemistry
Histones
/ metabolism
Humans
Lysine
/ metabolism
Methylation
Protein Binding
Proviruses
/ genetics
Transcription, Genetic
H3K9me3
HIV-1
RBMX
transcription
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Reversible repression of HIV-1 5' long terminal repeat (5'-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency. Identification of host factors that modulate LTR activity and viral latency may help develop new antiretroviral therapies. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are known to regulate gene expression and possess multiple physiological functions. hnRNP family members have recently been identified as the sensors for viral nucleic acids to induce antiviral responses, highlighting the crucial roles of hnRNPs in regulating viral infection. A member of the hnRNP family, X-linked RNA-binding motif protein (RBMX), has been identified in this study as a novel HIV-1 restriction factor that modulates HIV-1 5'-LTR-driven transcription of viral genome in CD4
Identifiants
pubmed: 32317327
pii: mBio.03424-19
doi: 10.1128/mBio.03424-19
pmc: PMC7175097
pii:
doi:
Substances chimiques
Heterogeneous-Nuclear Ribonucleoproteins
0
Histones
0
RBMX protein, human
0
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Ma et al.
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