Non-pharmacological treatment changes brain activity in patients with dementia.
Aged
Aged, 80 and over
Alpha Rhythm
/ physiology
Alzheimer Disease
/ diagnostic imaging
Beta Rhythm
/ physiology
Cognition
/ physiology
Cognitive Behavioral Therapy
/ methods
Dementia, Vascular
/ diagnostic imaging
Exercise
/ psychology
Female
Gamma Rhythm
/ physiology
Horticultural Therapy
/ methods
Humans
Magnetoencephalography
Male
Mental Status and Dementia Tests
Nursing Care
/ methods
Parietal Lobe
/ diagnostic imaging
Quality of Life
/ psychology
Role Playing
Temporal Lobe
/ diagnostic imaging
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
03
07
2019
accepted:
07
04
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Non-pharmacological treatment (NPT) improves cognitive functions and behavioural disturbances in patients with dementia, but the underlying neural mechanisms are unclear. In this observational study, 21 patients with dementia received NPTs for several months. Patients were scanned using magnetoencephalography twice during the NPT period to evaluate NPT effects on resting-state brain activity. Additionally, cognitive functions and behavioural disturbances were measured using the Mini-Mental State Examination (MMSE-J) and a short version of the Dementia Behaviour Disturbance Scale (DBD-13) at the beginning and the end of the NPT period. In contrast to the average DBD-13 score, the average MMSE-J score improved after the NPT period. Magnetoencephalography data revealed a reduced alpha activity in the right temporal lobe and fusiform gyrus, as well as an increased low-gamma activity in the right angular gyrus. DBD-13 score changes were correlated with beta activity in the sensorimotor area. These findings corroborate previous studies confirming NPT effects on brain activity in healthy participants and people at risk of dementia. Our results provide additional evidence that brains of patients with dementia have the capacity for plasticity, which may be responsible for the observed NPT effects. In dementia, NPT might lead to improvements in the quality of life.
Identifiants
pubmed: 32317774
doi: 10.1038/s41598-020-63881-0
pii: 10.1038/s41598-020-63881-0
pmc: PMC7174400
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6744Références
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