Value of High-Frequency Ultrasound in Accurate Staging of Mycosis Fungoides/Sézary Syndrome.
Sézary syndrome
cutaneous lymphoma
high-frequency ultrasound
mycosis fungoides
Journal
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
ISSN: 1550-9613
Titre abrégé: J Ultrasound Med
Pays: England
ID NLM: 8211547
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
21
02
2020
revised:
23
03
2020
accepted:
25
03
2020
pubmed:
23
4
2020
medline:
15
5
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
This study was aimed to assess the ultrasound (US) characteristics of mycosis fungoides (MF)/Sézary syndrome (SS) and explore the value of high-frequency US in accuracy staging for classic mycosis fungoides (cMF). A prospective study was designed. Twenty-six patients with histopathologically confirmed MF or SS were enrolled to undergo HF-US examinations. Both 50- and 20-MHz US images of the most prominent lesion of each patient were collected by a cutaneous diagnostic US system, and the US characteristics in different stages were analyzed by 2 physicians independently. The Fisher exact test was used for the statistical analysis. A total of 26 patients underwent this study, including 23 with cMF, 2 with folliculotropic mycosis fungoides (FMF), and 1 with SS. Among cMF, 16 patients with patches or plaques (the early-stage group) showed a subepidermal low-echogenic band, and only 3 lesions in the plaque stage partially extended to the superficial dermis. Seven patients with tumors (the advanced-stage group) showed lesions that infiltrated to the deep dermis or subcutaneous tissue. The infiltration depth (P < .001), clarity of the boundary (P = .002), and homogeneity of internal echoes (P = .001) were significantly different between the early and advanced stages. Additionally, the 2 FMF lesions and 1 SS lesion had characteristic manifestations, showing a well-defined subepidermal low-echogenic band with patchy hypoechoic regions around the hair follicles in the dermis. High-frequency US can be used to accurately detect the infiltration depth and morphologic features of MF/SS lesions and provide important information for tumor staging of cMF. Additionally, the characteristic US features in FMF and SS might be helpful for diagnosis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1927-1937Subventions
Organisme : Beijing Natural Science Foundation
ID : 7182127
Organisme : The CAMS Innovation Fund for Medical Sciences
ID : 2017-I2M-3-020 and 2017-I2M-1-006
Organisme : The Chinese Academy of Medical Sciences Clinical and Translational Medicine Research Fund
ID : 2019XK320024
Organisme : The National Key Research and Development Program of China
ID : 2016YFC0901500
Informations de copyright
© 2020 by the American Institute of Ultrasound in Medicine.
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