Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors.

Adult Aged Aged, 80 and over Biomarkers, Tumor / genetics Cohort Studies DNA Helicases / genetics DNA-Binding Proteins / genetics Humans Immune Checkpoint Inhibitors / therapeutic use Middle Aged Mutation Neoplasms / genetics Nuclear Proteins / genetics SMARCB1 Protein / genetics Survival Rate Transcription Factors / genetics Young Adult

Journal

Cancer immunology research

ISSN: 2326-6074

Titre abrégé: Cancer Immunol Res

Pays: United States

ID NLM: 101614637

Informations de publication

Date de publication:
08 2020

Historique:

received: 31 10 2019

revised: 10 01 2020

accepted: 16 04 2020

pubmed: 24 4 2020

medline: 20 1 2021

entrez: 24 4 2020

Statut: ppublish

Résumé

Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint inhibitors (ICI). Herein, we examined the association between mSWI/SNF variants and clinical outcomes to ICIs. We correlated somatic loss-of-function (LOF) variants in a predefined set of mSWI/SNF genes (

Identifiants

DOI: 10.1158/2326-6066.CIR-19-0866 PMID: 32321774 PMC: PMC7415546

pubmed: 32321774

pii: 2326-6066.CIR-19-0866

doi: 10.1158/2326-6066.CIR-19-0866

pmc: PMC7415546

mid: NIHMS1587095

doi:

Substances chimiques

ARID1A protein, human 0

ARID1B protein, human 0

ARID2 protein, human 0

Biomarkers, Tumor 0

DNA-Binding Proteins 0

Immune Checkpoint Inhibitors 0

Nuclear Proteins 0

PBRM1 protein, human 0

SMARCB1 Protein 0

SMARCB1 protein, human 0

Transcription Factors 0

SMARCA4 protein, human EC 3.6.1.-

DNA Helicases EC 3.6.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1075-1084

Subventions

Organisme : NCI NIH HHS

ID : P50 CA101942

Pays : United States

Organisme : NCI NIH HHS

ID : R01 CA234018

Pays : United States

Informations de copyright

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