Impact of HLA-B*52:01-Driven Escape Mutations on Viral Replicative Capacity.
Adult
Cohort Studies
Epitopes, T-Lymphocyte
/ immunology
Female
Genes, MHC Class I
Genotype
HIV Core Protein p24
/ genetics
HIV Infections
/ virology
HIV-1
/ immunology
HLA-B52 Antigen
/ genetics
Humans
Immune Evasion
/ genetics
Immunodominant Epitopes
/ genetics
Male
Mutation
T-Lymphocytes, Cytotoxic
/ immunology
Viral Load
Virus Replication
gag Gene Products, Human Immunodeficiency Virus
/ genetics
C clade
CTL
HLA
HLA-B*52:01
Indian
compensatory mutation
escape mutation
human immunodeficiency virus
p24 Gag
viral replicative capacity
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
27
01
2020
accepted:
10
04
2020
pubmed:
24
4
2020
medline:
18
12
2020
entrez:
24
4
2020
Statut:
epublish
Résumé
HLA-B*52:01 is strongly associated with protection against HIV disease progression. However, the mechanisms of HLA-B*52:01-mediated immune control have not been well studied. We here describe a cohort with a majority of HIV C-clade-infected individuals from Delhi, India, where HLA-B*52:01 is highly prevalent (phenotypic frequency, 22.5%). Consistent with studies of other cohorts, expression of HLA-B*52:01 was associated with high absolute CD4 counts and therefore a lack of HIV disease progression. We here examined the impact of HLA-B*52:01-associated viral polymorphisms within the immunodominant C clade Gag epitope RMTSPVSI (here, RI8; Gag residues 275 to 282) on viral replicative capacity (VRC) since HLA-mediated reduction in VRC is a central mechanism implicated in HLA-associated control of HIV. We observed in HLA-B*52:01-positive individuals a higher frequency of V280T, V280S, and V280A variants within RI8 (
Identifiants
pubmed: 32321820
pii: JVI.02025-19
doi: 10.1128/JVI.02025-19
pmc: PMC7307159
pii:
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
HIV Core Protein p24
0
HLA-B*52:01 antigen
0
HLA-B52 Antigen
0
Immunodominant Epitopes
0
gag Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI133673
Pays : United States
Organisme : Wellcome Trust
ID : WT104748MA
Pays : United Kingdom
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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