COVID-19 pathophysiology: A review.

Age Factors Aged Angiotensin-Converting Enzyme 2 Animals Betacoronavirus / immunology COVID-19 Child Coronavirus Infections / epidemiology Cytokines / genetics Disease Progression Disease Susceptibility Gene Expression Regulation Host-Pathogen Interactions / genetics Humans Mice Pandemics Peptidyl-Dipeptidase A / genetics Pneumonia, Viral / epidemiology SARS-CoV-2 Signal Transduction Spike Glycoprotein, Coronavirus / genetics T-Lymphocyte Subsets / immunology

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
06 2020
Historique:
received: 09 04 2020
revised: 14 04 2020
accepted: 16 04 2020
pubmed: 24 4 2020
medline: 24 6 2020
entrez: 24 4 2020
Statut: ppublish

Résumé

In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The number of death tolls continues to rise and a large number of countries have been forced to do social distancing and lockdown. Lack of targeted therapy continues to be a problem. Epidemiological studies showed that elder patients were more susceptible to severe diseases, while children tend to have milder symptoms. Here we reviewed the current knowledge about this disease and considered the potential explanation of the different symptomatology between children and adults.

Identifiants

DOI: 10.1016/j.clim.2020.108427 PMID: 32325252 PMC: PMC7169933
pubmed: 32325252
pii: S1521-6616(20)30262-X
doi: 10.1016/j.clim.2020.108427
pmc: PMC7169933
pii:
doi:

Substances chimiques

Cytokines 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Peptidyl-Dipeptidase A EC 3.4.15.1
ACE2 protein, human EC 3.4.17.23
Ace2 protein, mouse EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

108427

Subventions

Organisme : NICHD NIH HHS
ID : R21 HD099194
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118277
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

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Auteurs

Koichi Yuki (K)

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: koichi.yuki@childrens.harvard.edu.

Miho Fujiogi (M)

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: miho.fujiogi@childrens.harvard.edu.

Sophia Koutsogiannaki (S)

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: Sophia.koutsogiannaki@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Eucaryotes › Animaux › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › COVID-19 pathophysiology: A review.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › COVID-19 pathophysiology: A review.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › COVID-19 pathophysiology: A review.