The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-

AMP-Activated Protein Kinase Kinases Animals Aspalathus / chemistry Cells, Cultured Chalcones / isolation & purification DNA Damage / drug effects Energy Metabolism / drug effects Gene Expression / drug effects Glucose / adverse effects Glucosides / isolation & purification Membrane Potential, Mitochondrial / drug effects Metformin / pharmacology Myocytes, Cardiac / drug effects NADPH Oxidases / metabolism Oxidative Stress / drug effects PPAR alpha / metabolism Phenylpyruvic Acids / isolation & purification Protein Kinases / metabolism Rats Reactive Oxygen Species / metabolism
apoptosis aspalathin diabetes hyperglycemia oxidative stress phenylpropenoic acid glucoside rooibos

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
20 Apr 2020
Historique:
received: 27 03 2020
revised: 14 04 2020
accepted: 16 04 2020
entrez: 25 4 2020
pubmed: 25 4 2020
medline: 29 1 2021
Statut: epublish

Résumé

Recent evidence shows that rooibos compounds, aspalathin and phenylpyruvic acid-2-

Identifiants

DOI: 10.3390/nu12041151 PMID: 32325968 PMC: PMC7231041
pubmed: 32325968
pii: nu12041151
doi: 10.3390/nu12041151
pmc: PMC7231041
pii:
doi:

Substances chimiques

Chalcones 0
Glucosides 0
PPAR alpha 0
Phenylpyruvic Acids 0
Reactive Oxygen Species 0
aspalathin 0
Metformin 9100L32L2N
NADPH Oxidases EC 1.6.3.-
Protein Kinases EC 2.7.-
AMP-Activated Protein Kinase Kinases EC 2.7.11.3
Glucose IY9XDZ35W2
phenylpyruvic acid X7CO62M413

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : FIC NIH HHS
ID : D43 TW010131
Pays : United States
Organisme : National Research Foundiation (ZA)
ID : 117829 and 87836

Déclaration de conflit d'intérêts

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Références

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Auteurs

Phiwayinkosi V Dludla (PV)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.

Christo J F Muller (CJF)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Private Bag X1, Tygerberg 7505, South Africa.
Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3880, South Africa.

Johan Louw (J)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3880, South Africa.

Sithandiwe E Mazibuko-Mbeje (SE)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Private Bag X1, Tygerberg 7505, South Africa.

Luca Tiano (L)

Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.

Sonia Silvestri (S)

Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.

Patrick Orlando (P)

Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.

Fabio Marcheggiani (F)

Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.

Ilenia Cirilli (I)

Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
School of Pharmacy, University of Camerino, 62032 Camerino, Italy.

Nireshni Chellan (N)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Private Bag X1, Tygerberg 7505, South Africa.

Samira Ghoor (S)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.

Bongani B Nkambule (BB)

School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.

M Faadiel Essop (MF)

Centre for Cardio-metabolic Research in Africa, Department of Physiological Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.

Barbara Huisamen (B)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Private Bag X1, Tygerberg 7505, South Africa.

Rabia Johnson (R)

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Private Bag X1, Tygerberg 7505, South Africa.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-activated protein kinase kinases › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Eucaryotes › Animaux › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Aspalathus › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Cellules › Cellules cultivées › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chalcones › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Potentiel de membrane mitochondriale › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Pyruvates › Acides benzènepyruviques › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The Combination Effect of Aspalathin and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › The Combination Effect of Aspalathin and...