Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy.
cathepsins
lysosomal storage diseases
mucopolysaccharidoses
therapy
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
25
03
2020
revised:
13
04
2020
accepted:
14
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the endolysosomal compartment where they mediate protein degradation and turnover. However, CTSs are also found in the cytoplasm, nucleus, and extracellular matrix where they actively participate in cell signaling, protein processing, and trafficking through the plasma and nuclear membranes and between intracellular organelles. Dysregulation in CTS expression and/or activity disrupts cellular homeostasis, thus contributing to many human diseases, including inflammatory and cardiovascular diseases, neurodegenerative disorders, diabetes, obesity, cancer, kidney dysfunction, and others. This review aimed to highlight the involvement of CTSs in inherited lysosomal storage disorders, with a primary focus to the emerging evidence on the role of CTSs in the pathophysiology of Mucopolysaccharidoses (MPSs). These latter diseases are characterized by severe neurological, skeletal and cardiovascular phenotypes, and no effective cure exists to date. The advance in the knowledge of the molecular mechanisms underlying the activity of CTSs in MPSs may open a new challenge for the development of novel therapeutic approaches for the cure of such intractable diseases.
Identifiants
pubmed: 32326609
pii: cells9040979
doi: 10.3390/cells9040979
pmc: PMC7227001
pii:
doi:
Substances chimiques
Protease Inhibitors
0
Cathepsins
EC 3.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
PLoS One. 2015 Sep 01;10(9):e0137217
pubmed: 26325675
Mol Genet Metab. 2013 Nov;110(3):319-28
pubmed: 23856419
J Med Chem. 2017 Jan 26;60(2):658-667
pubmed: 28045523
Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G794-800
pubmed: 12181196
Hum Mol Genet. 2013 Apr 1;22(7):1417-23
pubmed: 23297359
Circulation. 2008 Apr 15;117(15):1973-81
pubmed: 18391110
Sci Rep. 2017 Apr 18;7:46576
pubmed: 28418018
Neurol Genet. 2016 Sep 16;2(5):e102
pubmed: 27668283
J Clin Med. 2018 Aug 28;7(9):
pubmed: 30154365
Mediators Inflamm. 2015;2015:293053
pubmed: 26185359
Biochim Biophys Acta. 2013 Nov;1832(11):1866-81
pubmed: 23402926
Mol Genet Metab. 2016 May;118(1):41-54
pubmed: 27053151
Ital J Pediatr. 2018 Nov 16;44(Suppl 2):121
pubmed: 30442188
J Cell Sci. 2019 Jan 16;132(2):
pubmed: 30651381
Anatol J Cardiol. 2016 Jan;16(1):23-8
pubmed: 26467359
Bone. 2016 Jul;88:92-100
pubmed: 27105565
Arch Rheumatol. 2018 Jan 22;33(4):498-504
pubmed: 30874236
Acta Neuropathol. 2009 Feb;117(2):201-8
pubmed: 18762956
Exp Ther Med. 2020 Jan;19(1):61-66
pubmed: 31853273
FEBS J. 2017 May;284(10):1437-1454
pubmed: 27926992
Neurobiol Aging. 2016 Oct;46:236.e1-6
pubmed: 27524508
J Inherit Metab Dis. 2011 Dec;34(6):1183-97
pubmed: 21744090
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17474-9
pubmed: 25422423
Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165539
pubmed: 31465828
Biomolecules. 2019 May 04;9(5):
pubmed: 31060228
Curr Drug Targets. 2007 Feb;8(2):315-23
pubmed: 17305509
Nat Rev Cardiol. 2018 Jun;15(6):351-370
pubmed: 29679024
Biochim Biophys Acta Mol Basis Dis. 2019 Nov 26;:165614
pubmed: 31783156
J Clin Pathol. 2020 Feb;73(2):76-82
pubmed: 31444238
Pain. 2019 Sep;160(9):2050-2062
pubmed: 31095099
Autophagy. 2013 Feb 1;9(2):241-3
pubmed: 23108186
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1284-1290
pubmed: 30017196
Cells. 2019 Oct 25;8(11):
pubmed: 31731485
Proteomics. 2016 Jan;16(1):150-8
pubmed: 26507101
Atherosclerosis. 2006 Feb;184(2):302-11
pubmed: 15982660
Expert Opin Drug Discov. 2016;11(5):457-72
pubmed: 27001692
Pediatr Dev Pathol. 2014 Nov-Dec;17(6):474-7
pubmed: 25075748
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10
pubmed: 24982147
J Cell Biol. 2012 Nov 26;199(5):723-34
pubmed: 23185029
Best Pract Res Clin Endocrinol Metab. 2015 Mar;29(2):219-35
pubmed: 25987175
Behav Neurol. 2017;2017:4261873
pubmed: 28133419
Neurology. 2014 Nov 4;83(19):1769-70
pubmed: 25274848
PLoS One. 2012;7(3):e32419
pubmed: 22403656
Am J Pathol. 2014 Oct;184(10):2730-41
pubmed: 25239563
Oncol Lett. 2020 Jan;19(1):167-176
pubmed: 31897127
Dokl Biochem Biophys. 2019 Jul;487(1):272-276
pubmed: 31559596
Br J Pharmacol. 2018 Apr;175(8):1157-1172
pubmed: 28631302
Pharmacol Ther. 2015 Nov;155:105-16
pubmed: 26299995
J Mol Graph Model. 2020 May;96:107512
pubmed: 31881466
Semin Cancer Biol. 2015 Dec;35:71-84
pubmed: 26320409
J Transl Med. 2018 May 9;16(1):125
pubmed: 29743078
Ital J Pediatr. 2018 Nov 16;44(Suppl 2):118
pubmed: 30442151
CNS Neurol Disord Drug Targets. 2008 Jun;7(3):270-7
pubmed: 18673211
Future Med Chem. 2018 Jan;10(1):5-26
pubmed: 29235371
Mol Genet Metab. 2008 Jul;94(3):298-304
pubmed: 18479957
PLoS One. 2015 Feb 03;10(2):e0117271
pubmed: 25646802
J Enzyme Inhib Med Chem. 2010 Oct;25(5):673-8
pubmed: 20063996
Exp Ther Med. 2017 Oct;14(4):3471-3476
pubmed: 29042935
Med Chem. 2012 Nov;8(6):1146-54
pubmed: 22830497
Hepatology. 2009 Apr;49(4):1297-307
pubmed: 19116891
Endocr Rev. 2017 Aug 1;38(4):325-350
pubmed: 28651365
Kidney Int. 2016 Nov;90(5):1012-1022
pubmed: 27575559
Ann Intern Med. 2020 Jan 21;172(2):86-95
pubmed: 31887743
Biochim Biophys Acta Mol Basis Dis. 2019 Oct 31;:165570
pubmed: 31678162
Pathol Res Pract. 2015 Jan;211(1):62-70
pubmed: 25433997
BMC Cancer. 2005 Jun 30;5:68
pubmed: 15989693
Biochimie. 2008 Feb;90(2):208-26
pubmed: 17935853
Cancers (Basel). 2019 Jan 19;11(1):
pubmed: 30669448
Brain. 2015 Feb;138(Pt 2):336-55
pubmed: 25567323
Exp Cell Res. 2009 Apr 15;315(7):1234-46
pubmed: 19331819
Int J Mol Sci. 2018 May 14;19(5):
pubmed: 29758010
Brain Res Bull. 2018 May;139:144-156
pubmed: 29454581
Atherosclerosis. 2018 Nov;278:97-102
pubmed: 30261474
Oncotarget. 2019 Aug 27;10(50):5217-5228
pubmed: 31497251
Proteomics Clin Appl. 2014 Jun;8(5-6):427-37
pubmed: 24677670
Int J Mol Sci. 2016 Dec 16;17(12):
pubmed: 27999266
Metabolism. 2001 Aug;50(8):905-11
pubmed: 11474477
Intractable Rare Dis Res. 2014 Aug;3(3):91-3
pubmed: 25364650
Int J Oncol. 2003 Jan;22(1):33-9
pubmed: 12469182
Neural Regen Res. 2020 Jan;15(1):25-29
pubmed: 31535638
Orphanet J Rare Dis. 2013 Aug 02;8:114
pubmed: 23915561
J Neurol. 2016 May;263(5):1029-1032
pubmed: 27072142
PLoS One. 2019 Dec 19;14(12):e0222055
pubmed: 31856175
Cardiovasc Pathol. 2017 Mar - Apr;27:45-50
pubmed: 28104572
Metab Brain Dis. 2017 Aug;32(4):973-975
pubmed: 28555253
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1143-54
pubmed: 25713304
Brain Pathol. 2019 Jan;29(1):63-74
pubmed: 30051532
EMBO J. 2019 Jan 15;38(2):
pubmed: 30530526
Circ Heart Fail. 2017 Jul;10(7):
pubmed: 28694354
Sci Rep. 2019 Nov 14;9(1):16774
pubmed: 31727956
Genes Dev. 2013 Oct 1;27(19):2086-98
pubmed: 24065739
Neural Regen Res. 2018 Dec;13(12):2100-2101
pubmed: 30323135
Sci Rep. 2018 May 18;8(1):7834
pubmed: 29777136
Eur J Orthop Surg Traumatol. 2018 Dec;28(8):1569-1572
pubmed: 29797092
Blood. 2005 Sep 15;106(6):1956-64
pubmed: 15947088
Curr Opin Neurobiol. 2013 Oct;23(5):767-73
pubmed: 23725858
J Biol Chem. 2018 Jan 19;293(3):1018-1029
pubmed: 29229780
J Vasc Surg. 2007 Dec;46(6):1260-6
pubmed: 18155003
Autophagy. 2016 Dec;12(12):2504-2505
pubmed: 27786577
Sci Rep. 2016 Feb 02;6:20101
pubmed: 26831567
Biomed Pharmacother. 2018 Sep;105:526-532
pubmed: 29885636
Biol Chem. 2011 Apr;392(6):555-69
pubmed: 21585286
Int J Mol Sci. 2019 Jul 27;20(15):
pubmed: 31357643
Curr Biol. 2016 Sep 12;26(17):2233-45
pubmed: 27498570
Lancet Neurol. 2019 Jan;18(1):107-116
pubmed: 30470609
J Bone Miner Res. 1999 Nov;14(11):1902-8
pubmed: 10571690
J Inherit Metab Dis. 2014 Jan;37(1):1-12
pubmed: 23653226
J Biol Chem. 1999 Oct 22;274(43):30433-8
pubmed: 10521421
Bioorg Chem. 2018 Dec;81:672-680
pubmed: 30253340
Curr Cancer Drug Targets. 2017;17(5):404-422
pubmed: 28215160
JIMD Rep. 2019;43:91-101
pubmed: 29923090
Ital J Pediatr. 2018 Nov 16;44(Suppl 2):124
pubmed: 30442204
Anemia. 2012;2012:201781
pubmed: 22550569
Biochem Pharmacol. 2019 Jun;164:349-367
pubmed: 30978322
Clin Genet. 2019 Oct;96(4):309-316
pubmed: 31237352
Pancreatology. 2019 Oct;19(7):951-956
pubmed: 31582345
Int J Neurosci. 2018 Jun;128(6):573-576
pubmed: 29120254
Sci Rep. 2017 Feb 27;7:43538
pubmed: 28240259
Osteoarthritis Cartilage. 2013 Dec;21(12):1813-23
pubmed: 23954699
Nature. 1965 Sep 4;207(5001):1102
pubmed: 5866314
J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):941-952
pubmed: 28860329
Folia Histochem Cytobiol. 2007;45(4):291-313
pubmed: 18165168
Mol Genet Metab Rep. 2019 Dec 20;22:100549
pubmed: 31890590
Front Mol Biosci. 2016 Oct 25;3:68
pubmed: 27826550
PLoS One. 2015 Jul 06;10(7):e0131662
pubmed: 26147524
Drugs. 2019 Jul;79(10):1103-1134
pubmed: 31209777
J Pediatr Rehabil Med. 2010;3(2):139-46
pubmed: 21629671
Expert Opin Ther Pat. 2011 Mar;21(3):311-37
pubmed: 21342054
J Neuroinflammation. 2017 Jun 6;14(1):115
pubmed: 28583160
Ann N Y Acad Sci. 2006 Nov;1085:161-9
pubmed: 17182932
Int J Exp Pathol. 2013 Oct;94(5):305-11
pubmed: 23786352
Sci Rep. 2017 Jun 14;7(1):3494
pubmed: 28615690
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093427
J Neurochem. 2019 Mar;148(5):639-651
pubmed: 30451296
Mol Genet Metab. 2019 Sep - Oct;128(1-2):62-67
pubmed: 31358474
J Biol Chem. 1998 Nov 27;273(48):32347-52
pubmed: 9822715
Calcif Tissue Int. 2003 Oct;73(4):380-6
pubmed: 12874701
Sci Rep. 2019 Jul 4;9(1):9682
pubmed: 31273243
Mol Neurodegener. 2019 Jan 16;14(1):4
pubmed: 30651094
Am J Pathol. 2004 Jun;164(6):2203-16
pubmed: 15161653
Int J Mol Sci. 2019 Jul 23;20(14):
pubmed: 31340550
Front Mol Neurosci. 2018 Nov 02;11:412
pubmed: 30450037
J Biol Chem. 1996 Feb 23;271(8):4403-9
pubmed: 8626791
Mol Genet Metab. 2017 Jul;121(3):227-240
pubmed: 28595941
Mol Med Rep. 2013 Aug;8(2):361-6
pubmed: 23732925
Future Med Chem. 2010 Jun;2(6):949-64
pubmed: 20640225
FEBS Lett. 2013 Apr 17;587(8):1258-67
pubmed: 23454643
Acta Pharm Sin B. 2015 Nov;5(6):506-19
pubmed: 26713267
Theranostics. 2017 Jul 30;7(11):2965-2967
pubmed: 28824729
J Clin Endocrinol Metab. 2010 Jun;95(6):2827-31
pubmed: 20357177
Biol Chem. 2004 May;385(5):439-45
pubmed: 15196006
Int J Mol Sci. 2017 May 17;18(5):
pubmed: 28513549
Hum Mutat. 2004 Mar;23(3):222-8
pubmed: 14974080
Biochim Biophys Acta. 2011 Nov;1812(11):1542-56
pubmed: 21827850
J Clin Invest. 2003 Aug;112(4):517-26
pubmed: 12925692
Am J Pathol. 2009 Nov;175(5):2053-62
pubmed: 19834056
J Med Chem. 2020 Feb 27;63(4):1576-1596
pubmed: 32003991
Gut. 2006 Sep;55(9):1228-30
pubmed: 16905693
Sci Rep. 2016 Jun 07;6:27112
pubmed: 27271556
PLoS One. 2012;7(4):e35787
pubmed: 22558223
Int Urol Nephrol. 2017 Aug;49(8):1409-1417
pubmed: 28534128
Brain. 2006 Jun;129(Pt 6):1438-45
pubmed: 16670177
Mol Ther Methods Clin Dev. 2018 Jun 18;10:8-16
pubmed: 29942826
Biomed Res Int. 2014;2014:309718
pubmed: 25587532
Pediatr Int. 2018 Aug;60(8):761-762
pubmed: 29987886
Neurology. 2014 Nov 11;83(20):1873-5
pubmed: 25298308
J Mol Histol. 2018 Oct;49(5):481-497
pubmed: 30046941
Neuromolecular Med. 2019 Sep;21(3):287-294
pubmed: 31134487
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1902-7
pubmed: 12576554
Mol Genet Metab. 2010 Apr;99(4):396-407
pubmed: 20044292
Chemistry. 2020 Feb 11;26(9):2002-2012
pubmed: 31692123
J Biol Chem. 2016 Apr 15;291(16):8486-99
pubmed: 26884336
J Biol Chem. 2007 Nov 9;282(45):33076-85
pubmed: 17726009
Cells. 2019 Mar 20;8(3):
pubmed: 30897858
J Clin Invest. 2010 Oct;120(10):3421-31
pubmed: 20921628
Molecules. 2020 Feb 06;25(3):
pubmed: 32041276
Int J Mol Sci. 2016 Nov 29;17(12):
pubmed: 27916847
Mol Genet Metab. 2011 May;103(1):18-25
pubmed: 21353610
Am J Hum Genet. 2006 Jun;78(6):988-98
pubmed: 16685649
Metab Brain Dis. 2011 Mar;26(1):9-19
pubmed: 21225451
Mol Genet Metab. 2018 Sep;125(1-2):4-17
pubmed: 30057281
J Pathol. 2005 Sep;207(1):32-42
pubmed: 16025436
Biochim Biophys Acta. 2013 Oct;1833(10):2254-66
pubmed: 23684953
Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40
pubmed: 25576872
Biochim Biophys Acta Proteins Proteom. 2020 Apr;1868(4):140360
pubmed: 31926332
Mol Genet Metab. 2011 Dec;104(4):608-19
pubmed: 21944884
Am J Hum Genet. 2013 Aug 8;93(2):313-20
pubmed: 23830514
Curr Opin Rheumatol. 2007 May;19(3):289-95
pubmed: 17414958
Microbiol Spectr. 2016 Jun;4(3):
pubmed: 27337470
Mol Genet Metab. 2018 Dec;125(4):322-331
pubmed: 30145178
Pharmacol Ther. 2018 Oct;190:202-236
pubmed: 29842917
J Clin Invest. 2003 Jul;112(2):152-9
pubmed: 12865404
JACC Basic Transl Sci. 2019 Jun 24;4(3):345-347
pubmed: 31312758
Int J Oral Sci. 2019 Jan 3;11(1):7
pubmed: 30602733
Expert Opin Ther Pat. 2017 Jun;27(6):643-656
pubmed: 27998201
J Biol Chem. 2000 Nov 10;275(45):35432-41
pubmed: 10945978
Front Cardiovasc Med. 2018 Jan 05;4:88
pubmed: 29379789
Cell Rep. 2019 Jul 23;28(4):1015-1028.e5
pubmed: 31340140
Life Sci. 2018 Mar 1;196:102-109
pubmed: 29366749
J Nat Prod. 2018 Jul 27;81(7):1673-1681
pubmed: 29944370
Expert Opin Orphan Drugs. 2017;5(2):131-141
pubmed: 28603679
Hum Mol Genet. 2017 May 1;26(9):1643-1655
pubmed: 28334757
Cell Signal. 2018 Jun;46:92-102
pubmed: 29501728
Matrix Biol. 2015 Mar;42:11-55
pubmed: 25701227
Atherosclerosis. 2013 Sep;230(1):100-105
pubmed: 23958260
Hum Genome Var. 2019 Apr 26;6:22
pubmed: 31044084
Cancer Lett. 2019 Oct 10;462:43-50
pubmed: 31381961
Am J Transl Res. 2017 Nov 15;9(11):5127-5137
pubmed: 29218110
J Mol Med (Berl). 2017 Oct;95(10):1107-1116
pubmed: 28791438
J Enzyme Inhib Med Chem. 2018 Dec;33(1):890-904
pubmed: 29723068
Neuropediatrics. 2018 Apr;49(2):150-153
pubmed: 29284168
Front Cell Dev Biol. 2017 Dec 19;5:114
pubmed: 29312937
Diabetes Metab Res Rev. 2019 Mar;35(3):e3117
pubmed: 30549421
Autophagy. 2019 Jun;15(6):1082-1099
pubmed: 30654731
Biochim Biophys Acta. 2015 Oct;1852(10 Pt B):2262-6
pubmed: 25989315
Bone. 2008 Jan;42(1):200-11
pubmed: 17962093
Nucleic Acids Res. 2018 Jan 4;46(D1):D624-D632
pubmed: 29145643
Ital J Pediatr. 2018 Nov 16;44(Suppl 2):133
pubmed: 30442162
Diabetologia. 2014 Aug;57(8):1674-83
pubmed: 24891017
Front Neurol. 2015 Sep 02;6:178
pubmed: 26388830
Neoplasma. 2015;62(1):16-26
pubmed: 25563363
Wien Med Wochenschr. 2015 May;165(9-10):210-3
pubmed: 26059544
Cell Death Dis. 2018 Jan 18;9(2):40
pubmed: 29348482
J Biol Chem. 2008 Jul 4;283(27):19140-50
pubmed: 18469004
Autophagy. 2020 May;16(5):811-825
pubmed: 31282275
Nat Rev Dis Primers. 2018 Oct 1;4(1):27
pubmed: 30275469
Mol Genet Metab. 2015 Feb;114(2):138-45
pubmed: 25541102
Eur Sci J. 2017 Oct;13:38-59
pubmed: 29805718
World J Gastroenterol. 2005 Oct 14;11(38):5951-7
pubmed: 16273605