Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model.
Animals
Antioxidants
/ pharmacology
Diabetes Mellitus, Experimental
/ chemically induced
Diabetes Mellitus, Type 2
/ chemically induced
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Hypoglycemic Agents
/ pharmacology
Male
Mitochondria
/ drug effects
Obesity
/ drug therapy
Organophosphorus Compounds
/ pharmacology
Peripheral Nervous System Diseases
/ chemically induced
Rats
Rats, Sprague-Dawley
Streptozocin
Ubiquinone
/ analogs & derivatives
Peripheral neuropathy
diabetes
mitoquinone
obesity
oxidative stress
Journal
Free radical research
ISSN: 1029-2470
Titre abrégé: Free Radic Res
Pays: England
ID NLM: 9423872
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
pubmed:
25
4
2020
medline:
15
12
2020
entrez:
25
4
2020
Statut:
ppublish
Résumé
This study sought to determine whether the addition of mitoquinone (Mito-Q) in the diet is an effective treatment for peripheral neuropathy in animal models of diet-induced obesity (pre-diabetes) and type 2 diabetes. Unlike other anti-oxidative stress compounds investigated as a treatment for peripheral neuropathy, Mito-Q specifically targets mitochondria. Although mito-Q has been shown to reduce oxidative stress generated by mitochondria there have been no studies performed of the effect of Mito-Q on peripheral neuropathy induced by diet-induced obesity or type 2 diabetes. Diet-induced obese (12 weeks after high fat diet) or type 2 diabetic rats (12 weeks of high fat diet and 4 weeks after the onset of hyperglycemia) were treated
Identifiants
pubmed: 32326763
doi: 10.1080/10715762.2020.1754409
pmc: PMC7329571
mid: NIHMS1589171
doi:
Substances chimiques
Antioxidants
0
Hypoglycemic Agents
0
Organophosphorus Compounds
0
Ubiquinone
1339-63-5
mitoquinone
47BYS17IY0
Streptozocin
5W494URQ81
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-318Subventions
Organisme : RRD VA
ID : I01 RX000889
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107399
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116624
Pays : United States
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