Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
Adherens Junctions
/ metabolism
Animals
Antigens, CD
/ metabolism
Blood-Air Barrier
/ cytology
Cadherins
/ metabolism
Endothelial Cells
/ cytology
Female
Humans
Male
Mice
Phospholipase D
/ metabolism
Phosphorylation
/ drug effects
Protein Tyrosine Phosphatases, Non-Receptor
/ metabolism
Thrombin
/ pharmacology
VE-cadherin
cadherin
endothelial barrier restoration
endothelial cell
endothelial dysfunction
lipid signaling
phosphatidic acid signaling
phospholipase D2 (PLD2)
phosphotyrosine signaling
protein tyrosine phosphatase non-receptor type 14 (PTPN14)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
29 05 2020
29 05 2020
Historique:
received:
11
11
2019
revised:
03
04
2020
pubmed:
25
4
2020
medline:
29
12
2020
entrez:
25
4
2020
Statut:
ppublish
Résumé
Increased permeability of vascular lung tissues is a hallmark of acute lung injury and is often caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin undergoes internalization in response to inflammatory stimuli and is recycled at cell adhesion junctions during endothelial barrier re-establishment. Here, we hypothesized that phospholipase D (PLD)-generated phosphatidic acid (PA) signaling regulates VE-cadherin recycling and promotes endothelial barrier recovery by dephosphorylating VE-cadherin. Genetic deletion of
Identifiants
pubmed: 32327488
pii: S0021-9258(17)49458-0
doi: 10.1074/jbc.RA119.011801
pmc: PMC7261798
doi:
Substances chimiques
Antigens, CD
0
Cadherins
0
cadherin 5
0
PTPN14 protein, human
EC 3.1.3.48
PTPN14 protein, mouse
EC 3.1.3.48
Protein Tyrosine Phosphatases, Non-Receptor
EC 3.1.3.48
phospholipase D2
EC 3.1.4.-
Phospholipase D
EC 3.1.4.4
Thrombin
EC 3.4.21.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7669-7685Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL060678
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075830
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA053840
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007829
Pays : United States
Informations de copyright
© 2020 Fu et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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