LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling.
Animals
Calcium
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Kinase
/ metabolism
Caspases, Initiator
/ genetics
Endoplasmic Reticulum
/ metabolism
Exosomes
/ metabolism
HMGB1 Protein
/ metabolism
Hepatocytes
/ metabolism
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Lipopolysaccharides
/ immunology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Phosphate-Binding Proteins
/ genetics
Sepsis
/ metabolism
Signal Transduction
Toll-Like Receptor 4
/ genetics
calcium
caspase-11
endotoxemia
extracellular vesicles
gasdermin D (GsdmD)
innate immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
11
2019
accepted:
28
01
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
19
3
2021
Statut:
epublish
Résumé
High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of lethality when released extracellularly during sepsis. The major source of circulating HMGB1 in sepsis is hepatocytes. However, the mechanism of HMGB1 release of hepatocytes during sepsis is not very clear. We have previously shown that bacterial endotoxin [lipopolysaccharide (LPS)] sensing pathways, including Toll-like receptor (TLR)4 and caspase-11, regulate hepatocyte HMGB1 release in response to LPS. Here, we report the novel function of caspase-11 and gasdermin D (GsdmD) in LPS-induced active HMGB1 released from hepatocytes. HMGB1 release during endotoxemia was caspase-11/GsdmD dependent via an active way
Identifiants
pubmed: 32328059
doi: 10.3389/fimmu.2020.00229
pmc: PMC7160675
doi:
Substances chimiques
Gsdmd protein, mouse
0
HMGB1 Protein
0
Intracellular Signaling Peptides and Proteins
0
Lipopolysaccharides
0
Phosphate-Binding Proteins
0
Toll-Like Receptor 4
0
Calcium-Calmodulin-Dependent Protein Kinase Kinase
EC 2.7.11.17
Casp4 protein, mouse
EC 3.4.22.-
Caspases, Initiator
EC 3.4.22.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
229Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM102146
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141080
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127027
Pays : United States
Informations de copyright
Copyright © 2020 Li, Deng, Loughran, Yang, Lin, Yang, Gao, Jin, Li, Cai, Lu, Billiar and Scott.
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