Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes.

Animals Cell Cycle / drug effects Cell Differentiation / drug effects Cells, Cultured Complement Membrane Attack Complex / pharmacology Myelin Sheath / drug effects Oligodendroglia / drug effects Phosphatidylinositol 3-Kinases / physiology Protein Kinase C / physiology Rats Rats, Sprague-Dawley Sirtuin 1 / physiology
C5b-9 SIRT1 cell cycle cyclin D1 oligodendrocyte

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 12 12 2019
accepted: 18 03 2020
entrez: 25 4 2020
pubmed: 25 4 2020
medline: 26 3 2021
Statut: epublish

Résumé

Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with surviving OLGs in multiple sclerosis (MS) plaques, but it is not yet known whether SIRT1 is involved in OLGs survival after exposure to sublytic C5b-9. We have now investigated the role of SIRT1 in OLGs differentiation and the effect of sublytic levels of C5b-9 on SIRT1 and phosphorylated-SIRT1 (Ser27) expression. We also examined the downstream effects of SIRT1 by measuring histone H3 lysine 9 trimethylation (H3K9me3) and the expression of cyclin D1 as a marker of cell cycle activation. OLG progenitor cells (OPCs) purified from the brain of rat pups were differentiated

Identifiants

DOI: 10.3389/fimmu.2020.00619 PMID: 32328069 PMC: PMC7160252
pubmed: 32328069
doi: 10.3389/fimmu.2020.00619
pmc: PMC7160252
doi:

Substances chimiques

Complement Membrane Attack Complex 0
Protein Kinase C EC 2.7.11.13
Sirt1 protein, rat EC 3.5.1.-
Sirtuin 1 EC 3.5.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

619

Informations de copyright

Copyright © 2020 Tatomir, Rao, Boodhoo, Vlaicu, Beltrand, Anselmo, Rus and Rus.

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Auteurs

Alexandru Tatomir (A)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Department of Neurosciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Gautam Rao (G)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

Dallas Boodhoo (D)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

Sonia I Vlaicu (SI)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Austin Beltrand (A)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

Freidrich Anselmo (F)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

Violeta Rus (V)

Division of Rheumatology and Immunology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.

Horea Rus (H)

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
Research Service, Veterans Administration Maryland Health Care System, Baltimore, MD, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Cellules › Cellules cultivées › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complexe d'attaque membranaire du complément › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Protéine kinase C › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Histone Deacetylase SIRT1 Mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-1 › Histone Deacetylase SIRT1 Mediates...