A retrospective cohort study evaluating correlates of deep tissue infections among patients enrolled in opioid agonist treatment using administrative data in Ontario, Canada.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
12
2019
accepted:
08
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
24
7
2020
Statut:
epublish
Résumé
The objective of this study was to evaluate the relationship between individual characteristics and deep tissue infections in patients enrolled in opioid agonist treatment in Ontario, Canada. A retrospective cohort study was conducted on patients in opioid agonist treatment between January 1, 2011, and December 31, 2015 in Ontario, Canada. Patients were identified using data from the Ontario Health Insurance Plan Database, and the Ontario Drug Benefit Plan Database. We identified other study variables including all-cause mortality using data from the Registered Persons Database. Encrypted patient identifiers were used to link across databases. Logistic regression models were used to measure potential correlates of deep tissue infections. An increase in the incidence of deep tissue infections was observed between 2011 and 2016 for patients on opioid agonist treatment. Additionally, age, sex, positive HIV diagnosis, and all-cause mortality was correlated with deep tissue infection in our study population. The study indicates factors that are associated with deep tissue infections in the opioid use disorder population and can be used to identify opportunities to reduce the incidence of new infections.
Identifiants
pubmed: 32330184
doi: 10.1371/journal.pone.0232191
pii: PONE-D-19-34949
pmc: PMC7182261
doi:
Substances chimiques
Analgesics, Opioid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0232191Déclaration de conflit d'intérêts
Dr. David Marsh maintains the following roles: Chief Medical Director at CATC (Canadian Addiction Treatment Center), opioid agonist therapy provider. Dr. Marsh has no ownership stake in the CATC as a stipendiary employee. We do not foresee any conflict of interest as data will be made freely available to the public and neither the CATC, nor the Universities, have the ability to prevent publication and dissemination of knowledge. The authors have no conflicts declared. This does not alter our adherence to PLOS ONE policies on sharing data and materials
Références
Arch Gen Psychiatry. 2001 May;58(5):503-8
pubmed: 11343531
West J Med. 1985 May;142(5):691-4
pubmed: 4013285
BMJ Case Rep. 2013 Jul 10;2013:
pubmed: 23845685
Rheumatology (Oxford). 2016 Dec;55(12):2176-2180
pubmed: 27638811
J Am Coll Cardiol. 2018 Apr 10;71(14):1596-1597
pubmed: 29622169
Am J Cardiol. 2017 Jan 15;119(2):317-322
pubmed: 27816113
Clin Epidemiol. 2016 Oct 19;8:389-392
pubmed: 27799820
Open Forum Infect Dis. 2016 Jul 26;3(3):ofw157
pubmed: 27800528
Clin Infect Dis. 2001 Jul 1;33(1):35-40
pubmed: 11389492
JAMA Intern Med. 2014 Dec;174(12):1974-81
pubmed: 25347412
Am J Med. 2005 Nov;118(11):1287
pubmed: 16271915
Drug Alcohol Depend. 2005 Aug 1;79(2):231-40
pubmed: 16002032
Can Fam Physician. 2014 Sep;60(9):826-32
pubmed: 25217680
Int J Popul Data Sci. 2018 Jan 10;3(1):2
pubmed: 30542668
Am J Med Sci. 2016 Dec;352(6):603-608
pubmed: 27916215
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004145
pubmed: 15495080
Can Psychiatr Assoc J. 1974 Feb;19(1):41-7
pubmed: 4149727
Am J Med. 2016 May;129(5):481-5
pubmed: 26597670
J Addict Dis. 2008;27(4):11-25
pubmed: 19042587
Harm Reduct J. 2018 Dec 4;15(1):59
pubmed: 30514384
J Am Acad Dermatol. 2005 Apr;52(4):704-5
pubmed: 15793530
Int J Drug Policy. 2017 Oct;48:1-8
pubmed: 28666202
Ann Rheum Dis. 2008 May;67(5):638-43
pubmed: 17901088
Am J Med. 2004 Feb 1;116(3):208-9
pubmed: 14749170
Healthc Q. 2016;18(4):8-11
pubmed: 27009700
Am J Public Health. 2017 Aug;107(8):1233-1239
pubmed: 28640689
CMAJ. 2018 Nov 5;190(44):E1294-E1295
pubmed: 30397155
Case Rep Infect Dis. 2013;2013:729812
pubmed: 24198986
Versicherungsmedizin. 1993 Feb 1;45(1):10-4
pubmed: 8438534
Drug Alcohol Depend. 2017 Feb 01;171:39-49
pubmed: 28013096
Rev Infect Dis. 1986 Nov-Dec;8(6):904-11
pubmed: 3099362
Subst Abuse Treat Prev Policy. 2019 Jun 26;14(1):29
pubmed: 31242949
J Urban Health. 2000 Sep;77(3):396-414
pubmed: 10976613
Am J Epidemiol. 2016 Mar 15;183(6):544-52
pubmed: 26865265
Int J Drug Policy. 2019 Feb;64:87-94
pubmed: 30641450
CMAJ Open. 2019 Apr 4;7(2):E197-E202
pubmed: 30948648
Prev Med. 2018 Feb;107:109-113
pubmed: 29126920
Harm Reduct J. 2017 Jan 26;14(1):6
pubmed: 28122579
Cochrane Database Syst Rev. 2009 Jul 08;(3):CD002209
pubmed: 19588333
Addiction. 1998 Apr;93(4):515-32
pubmed: 9684390
AIDS Behav. 2018 Jul;22(7):2214-2223
pubmed: 29557541
NCHS Data Brief. 2017 Dec;(294):1-8
pubmed: 29319475
Infection. 2018 Apr;46(2):245-251
pubmed: 29396671
Subst Abuse Treat Prev Policy. 2019 Jan 3;14(1):1
pubmed: 30606266
Postgrad Med J. 2016 Feb;92(1084):105-11
pubmed: 26719453
Clin Infect Dis. 2004 Jun 1;38 Suppl 5:S402-8
pubmed: 15156430
Heart Lung Circ. 2018 Apr;27(4):484-488
pubmed: 28533098
Drug Alcohol Depend. 2017 Jul 1;176:133-138
pubmed: 28535455
Am J Addict. 2016 Apr;25(3):191-4
pubmed: 26991660
Drug Alcohol Depend. 2015 Aug 1;153:152-8
pubmed: 26054944
Healthc Q. 2011;14(1):22-4
pubmed: 21301233
CMAJ Open. 2015 Jul 17;3(3):E344-51
pubmed: 26457294
Am J Epidemiol. 2009 Sep 15;170(6):783-92
pubmed: 19671835
Am J Public Health. 2015 Jun;105(6):1136-41
pubmed: 25880964
Addiction. 2017 Jul;112(7):1193-1201
pubmed: 28301070
Drug Alcohol Depend. 2017 Jul 1;176:89-95
pubmed: 28531769
Br J Dermatol. 2004 Jan;150(1):1-10
pubmed: 14746612
Curr Opin Cardiol. 2018 Mar;33(2):140-147
pubmed: 29232248
Infect Dis Clin North Am. 2002 Sep;16(3):681-95
pubmed: 12371122
CMAJ. 2015 Jul 14;187(10):717-718
pubmed: 26124228
Rev Infect Dis. 1980 Mar-Apr;2(2):196-206
pubmed: 6771865
Harm Reduct J. 2019 Feb 11;16(1):13
pubmed: 30744638
JBJS Case Connect. 2013 Oct 23;3(4 Suppl 2):e1011-6
pubmed: 29252256
Addiction. 2005 Feb;100(2):150-8
pubmed: 15679744
Psychiatry Res. 2014 Sep 30;219(1):191-7
pubmed: 24908543
Arch Intern Med. 2011 Apr 11;171(7):686-91
pubmed: 21482846
BMC Health Serv Res. 2019 Aug 7;19(1):553
pubmed: 31391048
Infection. 2014 Feb;42(1):207-10
pubmed: 23884723
JAMA. 2000 Oct 4;284(13):1689-95
pubmed: 11015800
Eur J Vasc Endovasc Surg. 2006 Oct;32(4):389-96
pubmed: 16682239
PLoS One. 2011;6(6):e21748
pubmed: 21738786
JAMA. 2011 Apr 6;305(13):1299-301
pubmed: 21467282
J Addict Med. 2015 Nov-Dec;9(6):440-6
pubmed: 26484843
J Am Board Fam Med. 2017 Nov-Dec;30(6):775-783
pubmed: 29180552
J Subst Abuse Treat. 2010 Jul;39(1):22-31
pubmed: 20418051