Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis.
COVID-19
Cardiac injury
Coronavirus
Mortality
Troponin
Journal
The American journal of emergency medicine
ISSN: 1532-8171
Titre abrégé: Am J Emerg Med
Pays: United States
ID NLM: 8309942
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
02
04
2020
revised:
13
04
2020
accepted:
14
04
2020
pubmed:
26
4
2020
medline:
4
6
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
Sections du résumé
Background
In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia.
Methods
We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19.
Results
There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34],
Conclusion
Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
Identifiants
pubmed: 32331955
pii: S0735-6757(20)30280-1
doi: 10.1016/j.ajem.2020.04.052
pmc: PMC7166308
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
352-357Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Elsevier Inc. All rights reserved.
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