Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease.


Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 06 2020
Historique:
received: 04 04 2019
accepted: 05 04 2020
pubmed: 26 4 2020
medline: 13 2 2021
entrez: 26 4 2020
Statut: ppublish

Résumé

Defects in biliary transport proteins, MDR3 in humans and Mdr2 in mice, can lead to a spectrum of cholestatic liver disorders. Although B cell disorders and the aberrant Ab production are the leading extrahepatic manifestations of cholestatic liver diseases, the mechanism underlying this phenomenon is incompletely understood. Using mice with deficiency of Mdr2 that progressively develop cholestatic liver disease, we investigated the contributions of BAFF to aberrant IgG autoantibody production and hepatic fibrosis. In

Identifiants

pubmed: 32332110
pii: jimmunol.1900391
doi: 10.4049/jimmunol.1900391
pmc: PMC7306885
mid: NIHMS1598784
doi:

Substances chimiques

Autoantibodies 0
B-Cell Activating Factor 0
Immunoglobulin G 0
Receptors, Antigen, B-Cell 0
Tnfsf13b protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

3117-3128

Subventions

Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136533
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR000165
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI096882
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK109025
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI126890
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124680
Pays : United States

Informations de copyright

Copyright © 2020 by The American Association of Immunologists, Inc.

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Auteurs

Manoj Thapa (M)

Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329; manoj.thapa@emory.edu arash.grakoui@emory.edu.

Dana Tedesco (D)

Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329.

Sanjeev Gumber (S)

Division of Pathology and Laboratory Medicine, Yerkes Research Primate Center, Emory University School of Medicine, Atlanta, GA 30329.

Elizabeth J Elrod (EJ)

Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329.

Jin-Hwan Han (JH)

Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329.

William H Kitchens (WH)

Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30329; and.

Joseph F Magliocca (JF)

Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30329; and.

Andrew B Adams (AB)

Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30329; and.

Arash Grakoui (A)

Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329; manoj.thapa@emory.edu arash.grakoui@emory.edu.
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329.

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