Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
10
10
2019
accepted:
08
04
2020
revised:
06
03
2020
pubmed:
26
4
2020
medline:
12
10
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Post-traumatic stress disorder (PTSD) is characterized by persistent fear memory of remote traumatic events, mental re-experiencing of the trauma, long-term cognitive deficits, and PTSD-associated hippocampal dysfunction. Extinction-based therapeutic approaches acutely reduce fear. However, many patients eventually relapse to the original conditioned fear response. Thus, understanding the underlying molecular mechanisms of this condition is critical to developing new treatments for patients. Mutations in the neuropsychiatric risk gene CACNA1C, which encodes the Ca
Identifiants
pubmed: 32332995
doi: 10.1038/s41380-020-0730-8
pii: 10.1038/s41380-020-0730-8
pmc: PMC8214244
mid: NIHMS1708118
doi:
Substances chimiques
CACNA1C protein, human
0
CACNA1C protein, mouse
0
Calcium Channels, L-Type
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2286-2298Subventions
Organisme : NCATS NIH HHS
ID : TL1 TR002386
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA029122
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078586
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA039080
Pays : United States
Informations de copyright
© 2020. The Author(s), under exclusive licence to Springer Nature Limited.
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