Activity of temocillin and comparators against urinary Escherichia coli and Klebsiella pneumoniae from Iran.
Anti-Bacterial Agents
/ pharmacology
Escherichia coli
/ drug effects
Escherichia coli Infections
/ drug therapy
Female
Humans
Iran
Klebsiella Infections
/ drug therapy
Klebsiella pneumoniae
/ drug effects
Male
Microbial Sensitivity Tests
Middle Aged
Penicillins
/ pharmacology
Urinary Tract Infections
/ drug therapy
Escherichia coli
Iran
Klebsiella pneumoniae
Temocillin
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
17
03
2020
accepted:
07
04
2020
pubmed:
26
4
2020
medline:
2
4
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
To evaluate the ground susceptibility of urinary Escherichia coli and Klebsiella pneumoniae to temocillin, the susceptibility of temocillin and comparators against 500 clinical isolates (231 E. coli and 269 K. pneumoniae) was tested. Temocillin was either found as the most active antibiotic (susceptibility rate of 92%) or the fourth most active antibiotic (65%), as per its urinary and systemic breakpoint, respectively. No difference of activity was observed in isolates expressing ESBL/AmpC enzymes. Considering the percentage of isolates expressing beta-lactamases and the need to spare broad-spectrum antibiotics, temocillin seems promising for treating urinary tract infections.
Identifiants
pubmed: 32333223
doi: 10.1007/s10096-020-03898-5
pii: 10.1007/s10096-020-03898-5
doi:
Substances chimiques
Anti-Bacterial Agents
0
Penicillins
0
temocillin
03QB156W6I
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
1793-1796Subventions
Organisme : Behbod Daru
ID : na