Cytokine-like Roles for Metabolites in Immunity.
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
04 06 2020
04 06 2020
Historique:
received:
17
10
2019
revised:
17
02
2020
accepted:
31
03
2020
pubmed:
26
4
2020
medline:
20
9
2020
entrez:
26
4
2020
Statut:
ppublish
Résumé
Metabolites have functions in the immune system independent of their conventional roles as sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering phase of gathering information about the functions of specific metabolites in immunoregulation. In this review, we cover succinate, itaconate, α-ketoglutarate, and lactate as examples. Each of these metabolites has a different story of how their immunoregulatory functions were discovered and how their roles in the complex process of inflammation were revealed. Parallels and interactions are emerging between metabolites and cytokines, well-known immunoregulators. We depict molecular mechanisms by which metabolites prime cellular and often physiological changes focusing on intra- and extra-cellular activities and signaling pathways. Possible therapeutic opportunities for immune and inflammatory diseases are emerging.
Identifiants
pubmed: 32333837
pii: S1097-2765(20)30228-8
doi: 10.1016/j.molcel.2020.04.002
pii:
doi:
Substances chimiques
Carboxylic Acids
0
Cytokines
0
Ketoglutaric Acids
0
Succinates
0
Lactic Acid
33X04XA5AT
Succinic Acid
AB6MNQ6J6L
itaconic acid
Q4516562YH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
814-823Subventions
Organisme : Wellcome Trust
ID : 109443/Z/15/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.