GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D
Adaptor Proteins, Vesicular Transport
/ metabolism
Endocytosis
HEK293 Cells
HeLa Cells
Humans
Intramolecular Oxidoreductases
/ metabolism
Lipocalins
/ metabolism
MAP Kinase Signaling System
Prostaglandin D2
/ metabolism
Protein Binding
Protein Transport
Receptors, Prostaglandin
/ metabolism
Signal Transduction
rab4 GTP-Binding Proteins
/ metabolism
DP1
GGA3
GPCR
L-PGDS
Rab4
Recycling
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
25
03
2020
revised:
15
04
2020
accepted:
15
04
2020
pubmed:
26
4
2020
medline:
4
8
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Mechanisms controlling the recycling of G protein-coupled receptors (GPCRs) remain largely unclear. We report that GGA3 (Golgi-associated, γ adaptin ear containing, ADP-ribosylation factor-binding protein 3) regulates the recycling and signaling of the PGD
Identifiants
pubmed: 32334026
pii: S0898-6568(20)30118-2
doi: 10.1016/j.cellsig.2020.109641
pii:
doi:
Substances chimiques
Adaptor Proteins, Vesicular Transport
0
GGA adaptor proteins
0
Lipocalins
0
Receptors, Prostaglandin
0
prostanoid D receptor 1, human
0
rab4 GTP-Binding Proteins
EC 3.6.5.2
Intramolecular Oxidoreductases
EC 5.3.-
prostaglandin R2 D-isomerase
EC 5.3.99.2
Prostaglandin D2
RXY07S6CZ2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109641Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.