Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.
Coxsackievirus and adenovirus receptor
Genetic variants
Viral infection
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
25 06 2020
25 06 2020
Historique:
received:
27
02
2020
accepted:
15
03
2020
pubmed:
27
4
2020
medline:
5
1
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
The Coxsackie- and adenovirus receptor (CAR) mediates homophilic cell-cell contacts and susceptibility to both human pathogenic viruses through its membrane-distal immunoglobulin domain. In the present study, we screened five missense variants of the human CAR gene for their influence on adenovector or Coxsackievirus entry into Chinese hamster ovary cells. The CAR variants facilitated virus internalisation to a similar extent as wild type CAR. This underlines CAR's presumed invariance and essential physiological role in embryogenesis.
Identifiants
pubmed: 32334832
pii: S0006-291X(20)30567-2
doi: 10.1016/j.bbrc.2020.03.082
pii:
doi:
Substances chimiques
Coxsackie and Adenovirus Receptor-Like Membrane Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-405Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.