An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function.
ex vivo lung perfusion
lung preservation
lung transplantation
oxygen carriers
prolonged preservation
Journal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Titre abrégé: J Heart Lung Transplant
Pays: United States
ID NLM: 9102703
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
01
2020
revised:
06
03
2020
accepted:
25
03
2020
pubmed:
27
4
2020
medline:
7
7
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
The use of a novel extracellular oxygen carrier (EOC) preservation additive known as HEMO Donor pigs were randomly allocated to either of the following 2 groups (n = 6 per group): (1) 36 hours cold preservation or (2) 36 hours cold preservation with 1 g/liter of EOC. The lungs were evaluated through 12 hours of normothermic ex vivo lung perfusion (EVLP) followed by a left-single lung transplant into a recipient pig. Grafts were reperfused for 4 hours, followed by right pulmonary artery clamping to assess graft oxygenation function. During EVLP assessment, EOC-treated lungs showed improvements in physiologic parameters, whereas the control lungs deteriorated. After a total of 48 hours of preservation (36 hours cold + 12 hours normothermic EVLP), transplanted grafts in the treatment group displayed significantly better oxygenation than in the controls (PaO The use of an EOC during an extended pulmonary preservation period led to significantly superior early post-transplant lung function.
Sections du résumé
BACKGROUND
The use of a novel extracellular oxygen carrier (EOC) preservation additive known as HEMO
METHODS
Donor pigs were randomly allocated to either of the following 2 groups (n = 6 per group): (1) 36 hours cold preservation or (2) 36 hours cold preservation with 1 g/liter of EOC. The lungs were evaluated through 12 hours of normothermic ex vivo lung perfusion (EVLP) followed by a left-single lung transplant into a recipient pig. Grafts were reperfused for 4 hours, followed by right pulmonary artery clamping to assess graft oxygenation function.
RESULTS
During EVLP assessment, EOC-treated lungs showed improvements in physiologic parameters, whereas the control lungs deteriorated. After a total of 48 hours of preservation (36 hours cold + 12 hours normothermic EVLP), transplanted grafts in the treatment group displayed significantly better oxygenation than in the controls (PaO
CONCLUSION
The use of an EOC during an extended pulmonary preservation period led to significantly superior early post-transplant lung function.
Identifiants
pubmed: 32334946
pii: S1053-2498(20)31488-1
doi: 10.1016/j.healun.2020.03.027
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-603Informations de copyright
Copyright © 2020 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.