Strong diffusion gradients allow the separation of intra- and extra-axonal gradient-echo signals in the human brain.
Adult
Anisotropy
Axons
Brain
/ diagnostic imaging
Connectome
Diffusion Magnetic Resonance Imaging
/ methods
Echo-Planar Imaging
Electromagnetic Fields
Female
Humans
Image Processing, Computer-Assisted
/ methods
Male
Nerve Fibers
/ ultrastructure
Neural Pathways
/ diagnostic imaging
Pyramidal Tracts
/ diagnostic imaging
White Matter
/ diagnostic imaging
MRI contrast mechanisms
Microstructure
Myelin
White matter
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
12
09
2019
revised:
28
02
2020
accepted:
19
03
2020
pubmed:
27
4
2020
medline:
20
2
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
The quantification of brain white matter properties is a key area of application of Magnetic Resonance Imaging (MRI), with much effort focused on using MR techniques to quantify tissue microstructure. While diffusion MRI probes white matter (WM) microstructure by characterising the sensitivity of Brownian motion of water molecules to anisotropic structures, susceptibility-based techniques probe the tissue microstructure by observing the effect of interaction between the tissue and the magnetic field. Here, we unify these two complementary approaches by combining ultra-strong (300mT/m) gradients with a novel Diffusion-Filtered Asymmetric Spin Echo (D-FASE) technique. Using D-FASE we can separately assess the evolution of the intra- and extra-axonal signals under the action of susceptibility effects, revealing differences in the behaviour in different fibre tracts. We observed that the effective relaxation rate of the ASE signal in the corpus callosum decreases with increasing b-value in all subjects (from 17.1±0.7s
Identifiants
pubmed: 32335263
pii: S1053-8119(20)30280-9
doi: 10.1016/j.neuroimage.2020.116793
pmc: PMC7613126
mid: EMS150877
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116793Subventions
Organisme : Wellcome Trust
ID : 104943/Z/14/Z
Pays : United Kingdom
Organisme : Dutch Research Council
ID : NWO_680-50-1527
Pays : Netherlands
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104943
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 096646/Z/11/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 096646
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
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