Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation.


Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
19 06 2020
Historique:
pubmed: 28 4 2020
medline: 13 4 2021
entrez: 28 4 2020
Statut: ppublish

Résumé

We have previously identified the natural product obtusaquinone (OBT) as a potent antineoplastic agent with promising

Identifiants

pubmed: 32338864
doi: 10.1021/acschembio.0c00104
pmc: PMC7995447
mid: NIHMS1678726
doi:

Substances chimiques

Antineoplastic Agents 0
Cinnamates 0
Cyclohexanones 0
Kelch-Like ECH-Associated Protein 1 0
obtusaquinone 62745-67-9
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1445-1454

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS064983
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025504
Pays : United States

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Auteurs

Christian E Badr (CE)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Cintia Carla da Hora (CC)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Aleksandar B Kirov (AB)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Elie Tabet (E)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Romain Amante (R)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Semer Maksoud (S)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Antoinette E Nibbs (AE)

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Evelyn Fitzsimons (E)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

Myriam Boukhali (M)

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, United States.

John W Chen (JW)

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.

Norman H L Chiu (NHL)

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Caroline 27402, United States.

Ichiro Nakano (I)

Department of Neurosurgery and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.

Wilhelm Haas (W)

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, United States.

Ralph Mazitschek (R)

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Broad Institute of Harvard & Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, United States.

Bakhos A Tannous (BA)

Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

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Classifications MeSH