Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2 Cells.

Adenine Amino Acid Transport Systems / metabolism Biological Transport Equilibrative Nucleoside Transporter 1 / genetics Equilibrative-Nucleoside Transporter 2 / genetics Hep G2 Cells Humans
Facilitated transport Hepatic transport Inhibition In vitro model Membrane transport Membrane transporter Solute carrier (SLC) transporter

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
08 2020
Historique:
received: 19 01 2020
revised: 24 03 2020
accepted: 20 04 2020
pubmed: 28 4 2020
medline: 22 6 2021
entrez: 28 4 2020
Statut: ppublish

Résumé

Equilibrative nucleobase transporter 1 (ENBT1/SLC43A3) has recently been identified as a purine-selective nucleobase transporter. Although it is highly expressed in the liver, its role in nucleobase transport has not been confirmed yet in hepatocytes or any relevant cell models. We, therefore, examined its role in adenine transport in the HepG2 cell line as a human hepatocyte model. The uptake of [

Identifiants

DOI: 10.1016/j.xphs.2020.04.013 PMID: 32339528
pubmed: 32339528
pii: S0022-3549(20)30206-9
doi: 10.1016/j.xphs.2020.04.013
pii:
doi:

Substances chimiques

Amino Acid Transport Systems 0
Equilibrative Nucleoside Transporter 1 0
Equilibrative-Nucleoside Transporter 2 0
SLC43A3 protein, human 0
Adenine JAC85A2161

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2622-2628

Informations de copyright

Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Risa Takenaka (R)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

Tomoya Yasujima (T)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. Electronic address: yasujima@phar.nagoya-cu.ac.jp.

Junji Furukawa (J)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

Yosuke Hishikawa (Y)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

Takahiro Yamashiro (T)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

Kinya Ohta (K)

College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya 463-8521, Japan.

Katsuhisa Inoue (K)

Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

Hiroaki Yuasa (H)

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › Functional Analysis of the Role of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Systèmes de transport d'acides aminés › Functional Analysis of the Role of...
questionsmedicales.fr › Métabolisme › Transport biologique › Functional Analysis of the Role of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 1 › Functional Analysis of the Role of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 2 › Functional Analysis of the Role of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Functional Analysis of the Role of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional Analysis of the Role of...