Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
27
12
2019
revised:
10
04
2020
accepted:
13
04
2020
pubmed:
28
4
2020
medline:
12
2
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
To investigate use of a novel imaging approach, hyperpolarized (HP) Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice (n = 18) underwent single-fraction RT (4-14 Gy steep dose across the tumor) and were imaged serially at pre-RT baseline and 1, 4, and 7 days after RT using HP We found a significant decrease in HP pyruvate-to-lactate conversion in tumors responding to RT, with concomitant significant increases in HP pyruvate-to-alanine conversion and HP urea signal; the opposite changes were observed in tumors resistant to RT. Moreover, HP lactate change was dependent on radiation dose; tumor regions treated with higher radiation doses (10-14 Gy) exhibited a greater decrease in HP lactate signal than low-dose regions (4-7 Gy) as early as 1 day post-RT, consistent with lactate dehydrogenase enzyme activity and expression data. We also found that HP [ These results demonstrate the ability of HP
Identifiants
pubmed: 32339646
pii: S0360-3016(20)31042-7
doi: 10.1016/j.ijrobp.2020.04.022
pmc: PMC7381368
mid: NIHMS1587698
pii:
doi:
Substances chimiques
Carbon Isotopes
0
Pyruvic Acid
8558G7RUTR
Urea
8W8T17847W
Carbon-13
FDJ0A8596D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
887-896Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB013598
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166655
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166766
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214554
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
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