Resveratrol prevents ISO-induced myocardial remodeling associated with regulating polarization of macrophages through VEGF-B/AMPK/NF-kB pathway.
AMP-Activated Protein Kinases
/ immunology
Animals
Cytokines
/ genetics
Isoproterenol
Macrophages
/ drug effects
Male
Mice
Mice, Inbred BALB C
Myocardium
/ pathology
NF-kappa B
/ immunology
RAW 264.7 Cells
RNA, Small Interfering
/ genetics
Resveratrol
/ pharmacology
Signal Transduction
/ drug effects
Vascular Endothelial Growth Factor B
/ genetics
Ventricular Remodeling
/ drug effects
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
08
12
2019
revised:
06
04
2020
accepted:
10
04
2020
pubmed:
28
4
2020
medline:
11
3
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Macrophage expansion and inflammatory responses are involved in induction of cardiac remodeling. Resveratrol has strong anti-inflammatory effects, however its effect on macrophage infiltration and polarization is unknown. This study aimed to investigate the anti-inflammatory effects of RSV on ISO-induced myocardial remodeling in mice and its regulatory role in macrophage polarization. BALB/c mice were orally administered with RSV (100 mg/kg) daily for one week, then were subcutaneously injected with ISO (50 mg/kg) daily for another week. ISO injections to mouse caused cardiac dysfunction evidenced by cardiac hypertrophy and cardiomyocyte fibrosis. Meanwhile, macrophage M1 polarization was found in ISO treated mice, which was evidenced by increased percentage of Ly6C
Identifiants
pubmed: 32339921
pii: S1567-5769(19)32873-5
doi: 10.1016/j.intimp.2020.106508
pii:
doi:
Substances chimiques
Cytokines
0
NF-kappa B
0
RNA, Small Interfering
0
Vascular Endothelial Growth Factor B
0
vascular endothelial growth factor B, mouse
0
AMP-Activated Protein Kinases
EC 2.7.11.31
Isoproterenol
L628TT009W
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106508Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.