Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness.

Antineoplastic Agents / pharmacology Apoptosis / drug effects Carbonic Anhydrase IX / antagonists & inhibitors Carbonic Anhydrase Inhibitors / pharmacology Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects Dose-Response Relationship, Drug Gene Expression Humans Isoenzymes Matrix Metalloproteinase 2
Carbonic anhydrase IX apoptosis cancer cells epithelial-mesenchymal transition invasiveness

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Apr 2020
Historique:
received: 18 03 2020
revised: 18 04 2020
accepted: 20 04 2020
entrez: 29 4 2020
pubmed: 29 4 2020
medline: 30 1 2021
Statut: epublish

Résumé

Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO

Identifiants

DOI: 10.3390/ijms21082983 PMID: 32340282 PMC: PMC7215745
pubmed: 32340282
pii: ijms21082983
doi: 10.3390/ijms21082983
pmc: PMC7215745
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Carbonic Anhydrase Inhibitors 0
Isoenzymes 0
Matrix Metalloproteinase 2 EC 3.4.24.24
Carbonic Anhydrase IX EC 4.2.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : MIUR-PRIN
ID : 2015Y3C5KP

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Auteurs

Valerio Ciccone (V)

Department of Life Sciences, University of Siena, 53100 Siena, Italy.
ORCID: 0000-0002-5374-9694

Arianna Filippelli (A)

Department of Life Sciences, University of Siena, 53100 Siena, Italy.

Andrea Angeli (A)

Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università di Firenze, Sesto Fiorentino, 50139 Firenze, Italy.
ORCID: 0000-0002-1470-7192

Claudiu T Supuran (CT)

Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università di Firenze, Sesto Fiorentino, 50139 Firenze, Italy.
ORCID: 0000-0003-4262-0323

Lucia Morbidelli (L)

Department of Life Sciences, University of Siena, 53100 Siena, Italy.
ORCID: 0000-0001-8148-7049

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Carbonic anhydrase IX › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Pharmacological Inhibition of CA-IX Impairs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 2 › Pharmacological Inhibition of CA-IX Impairs...