Dysbiosis of Fecal Microbiota in Allergic Rhinitis Patients.

Dysbiosis / complications Humans Microbiota Phylogeny RNA, Ribosomal, 16S Rhinitis, Allergic / complications
Prevotella allergic rhinitis allergy gut microbiome purine pyruvate

Journal

American journal of rhinology & allergy
ISSN: 1945-8932
Titre abrégé: Am J Rhinol Allergy
Pays: United States
ID NLM: 101490775

Informations de publication

Date de publication:
Sep 2020
Historique:
pubmed: 29 4 2020
medline: 10 8 2021
entrez: 29 4 2020
Statut: ppublish

Résumé

The gut microbiota plays an important role in shaping the immune system and may be closely connected to the development of allergic diseases. This study aimed to determine the gut microbiota composition in Chinese allergic rhinitis (AR) patients as compared with healthy controls (HCs). We collected stool samples from 93 AR patients and 72 age- and sex-matched HCs. Gut microbiota composition was analyzed using QIIME targeting the 16S rRNA gene. Functional pathways were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States. Statistical analysis was performed using the Compared with HCs, AR patients had significantly lower gut-microbiota α-diversity ( A comparison of the gut microbiota of AR patients and HCs suggested that dysbiosis of the fecal microbiota is involved in the development of AR. The present results may reveal key differences and identify targets for preventive or therapeutic intervention.

Sections du résumé

BACKGROUND BACKGROUND
The gut microbiota plays an important role in shaping the immune system and may be closely connected to the development of allergic diseases.
OBJECTIVE OBJECTIVE
This study aimed to determine the gut microbiota composition in Chinese allergic rhinitis (AR) patients as compared with healthy controls (HCs).
METHODS METHODS
We collected stool samples from 93 AR patients and 72 age- and sex-matched HCs. Gut microbiota composition was analyzed using QIIME targeting the 16S rRNA gene. Functional pathways were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States. Statistical analysis was performed using the
RESULTS RESULTS
Compared with HCs, AR patients had significantly lower gut-microbiota α-diversity (
CONCLUSION CONCLUSIONS
A comparison of the gut microbiota of AR patients and HCs suggested that dysbiosis of the fecal microbiota is involved in the development of AR. The present results may reveal key differences and identify targets for preventive or therapeutic intervention.

Identifiants

DOI: 10.1177/1945892420920477 PMID: 32340468
pubmed: 32340468
doi: 10.1177/1945892420920477
doi:

Substances chimiques

RNA, Ribosomal, 16S 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

650-660

Auteurs

Xiang Liu (X)

Department of Otolaryngology and Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Jing Tao (J)

Department of ENT and Head and Neck Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Jing Li (J)

Department of Otolaryngology and Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Xiaolin Cao (X)

Department of Otolaryngology and Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yong Li (Y)

Department of Otolaryngology and Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Xuefeng Gao (X)

Department of Gastroenterology and Hepatology, Shenzhen University General Hospital, Shenzhen, Guangdong, China.

Yong Fu (Y)

Department of ENT and Head and Neck Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
ORCID: 0000-0003-4570-2973

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Dysbiosis of Fecal Microbiota in Allergic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dysbiosis of Fecal Microbiota in Allergic...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Dysbiosis of Fecal Microbiota in Allergic...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Dysbiosis of Fecal Microbiota in Allergic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Dysbiosis of Fecal Microbiota in Allergic...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Rhinite allergique › Dysbiosis of Fecal Microbiota in Allergic...