Intestinal Microbiota, HLA-B27, and Spondyloarthritis: Dangerous Liaisons.

Disease Progression Gastrointestinal Microbiome / genetics HLA-B27 Antigen / genetics Humans Spondylarthritis / complications
HLA-B27 Innate mucosal immunity Microbiota Spondyloarthritis

Journal

Rheumatic diseases clinics of North America
ISSN: 1558-3163
Titre abrégé: Rheum Dis Clin North Am
Pays: United States
ID NLM: 8708093

Informations de publication

Date de publication:
05 2020
Historique:
entrez: 29 4 2020
pubmed: 29 4 2020
medline: 9 10 2021
Statut: ppublish

Résumé

Spondyloarthritis, although primarily a joint-centered disease, is associated with extra-articular features, such as gut inflammation, psoriasis, and/or uveitis. Evidence points to underlying genetic predisposing factors and/or environmental factors. This is most clear in the gut, with progress through 16S and metagenomics sequencing studies and the results of functional studies in preclinical arthritis models. Translation of these findings to the clinic is making progress based on encouraging results of fecal microbial transplant studies in several human diseases. This review elaborates on novel trends in host-microbial interplay in spondyloarthritis, focusing on microbiota, immune dysregulation, and disease progression, and modulation by HLA-B27.

Identifiants

DOI: 10.1016/j.rdc.2020.01.007 PMID: 32340697
pubmed: 32340697
pii: S0889-857X(20)30007-7
doi: 10.1016/j.rdc.2020.01.007
pii:
doi:

Substances chimiques

HLA-B27 Antigen 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

213-224

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to declare.

Auteurs

Emilie Dumas (E)

Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics (Rheumatology Unit), Ghent University, Corneel Heymanslaan 10, Gent 9000, Belgium; Molecular Immunology and Inflammation Unit, VIB Center for Inflammatory Research, Ghent, Belgium.

Koen Venken (K)

Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics (Rheumatology Unit), Ghent University, Corneel Heymanslaan 10, Gent 9000, Belgium; Molecular Immunology and Inflammation Unit, VIB Center for Inflammatory Research, Ghent, Belgium.

James T Rosenbaum (JT)

Oregon Health & Science University, Portland, OR, USA; Legacy Devers Eye Institute, Portland, OR, USA.

Dirk Elewaut (D)

Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics (Rheumatology Unit), Ghent University, Corneel Heymanslaan 10, Gent 9000, Belgium; Molecular Immunology and Inflammation Unit, VIB Center for Inflammatory Research, Ghent, Belgium. Electronic address: dirk.elewaut@ugent.be.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Intestinal Microbiota, HLA-B27, and...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Intestinal Microbiota, HLA-B27, and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-B › Antigène HLA-B27 › Intestinal Microbiota, HLA-B27, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intestinal Microbiota, HLA-B27, and...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Arthrite › Spondylarthrite › Intestinal Microbiota, HLA-B27, and...