What Does Human Leukocyte Antigen B27 Have to Do with Spondyloarthritis?
Diagnosis
Disease phenotype
Genetics
HLA-B27
Prognosis
Spondyloarthritis
Journal
Rheumatic diseases clinics of North America
ISSN: 1558-3163
Titre abrégé: Rheum Dis Clin North Am
Pays: United States
ID NLM: 8708093
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
9
10
2021
Statut:
ppublish
Résumé
Human leukocyte antigen (HLA) B27 is the key laboratory parameter for axial spondyloarthritis (axSpA). Its prevalence is variable across different geographic zones and ethnicities, and often mirrors the prevalence of axSpA. HLA-B27 plays a role in axSpA physiopathology. It is correlated with spondyloarthritis phenotype with a consistent positive association with family history, early disease onset, shorter diagnostic delay, hip involvement, and acute anterior uveitis. HLA-B27 has a pivotal role in many referral strategies. However, these strategies were developed in European populations and need to be evaluated in populations with lower HLA-B27 background prevalence, and where additional parameters might be needed.
Identifiants
pubmed: 32340698
pii: S0889-857X(20)30002-8
doi: 10.1016/j.rdc.2020.01.002
pii:
doi:
Substances chimiques
HLA-B27 Antigen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-239Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The authors have nothing to disclose.