Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.
Adult
Asian People
/ genetics
Follicle Stimulating Hormone
/ genetics
Genome-Wide Association Study
Humans
Inhibins
/ blood
Luteinizing Hormone
/ blood
Male
Organ Size
Polymorphism, Single Nucleotide
Semen
/ metabolism
Semen Analysis
Sex Hormone-Binding Globulin
/ genetics
Sperm Count
Testis
/ growth & development
Testosterone
/ blood
Journal
Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
10
12
2019
accepted:
30
03
2020
revised:
29
03
2020
pubmed:
29
4
2020
medline:
18
11
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
Semen quality is affected by environmental factors, endocrine function abnormalities, and genetic factors. A GWAS recently identified ERBB4 at 2q34 as a genetic locus associated with sperm motility. However, GWASs for human semen volume and sperm concentration have not been conducted. In addition, testis size also reportedly correlates with semen quality, and it is important to identify genes that affect testis size. Reproductive hormones also play an important role in spermatogenesis. To date, genetic loci associated with plasma testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels have been identified using GWASs. However, GWASs have not identified any relevant loci for plasma inhibin B levels. We conducted a two-stage GWAS using 811 Japanese men in a discovery stage followed by a replication stage using an additional 721 Japanese men. The results of the discovery and replication stages were combined into a meta-analysis. After setting a suggestive significance threshold for P values < 5 × 10
Identifiants
pubmed: 32341457
doi: 10.1038/s10038-020-0757-3
pii: 10.1038/s10038-020-0757-3
doi:
Substances chimiques
Sex Hormone-Binding Globulin
0
inhibin B
0
Testosterone
3XMK78S47O
Inhibins
57285-09-3
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-691Références
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