Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis.


Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
05 2020
Historique:
received: 19 10 2019
accepted: 28 01 2020
entrez: 29 4 2020
pubmed: 29 4 2020
medline: 28 7 2020
Statut: ppublish

Résumé

The multidrug-resistant Staphylococcus capitis NRCS-A clone is responsible for sepsis in preterm infants in neonatal intensive care units (NICUs) worldwide. Here, to retrace the spread of this clone and to identify drivers of its specific success, we investigated a representative collection of 250 S. capitis isolates from adults and newborns. Bayesian analyses confirmed the spread of the NRCS-A clone and enabled us to date its emergence in the late 1960s and its expansion during the 1980s, coinciding with the establishment of NICUs and the increasing use of vancomycin in these units, respectively. This dynamic was accompanied by the acquisition of mutations in antimicrobial resistance- and bacteriocin-encoding genes. Furthermore, combined statistical tools and a genome-wide association study convergently point to vancomycin resistance as a major driver of NRCS-A success. We also identified another S. capitis subclade (alpha clade) that emerged independently, showing parallel evolution towards NICU specialization and non-susceptibility to vancomycin, indicating convergent evolution in NICU-associated pathogens. These findings illustrate how the broad use of antibiotics can repeatedly lead initially commensal drug-susceptible bacteria to evolve into multidrug-resistant clones that are able to successfully spread worldwide and become pathogenic for highly vulnerable patients.

Identifiants

pubmed: 32341568
doi: 10.1038/s41564-020-0676-2
pii: 10.1038/s41564-020-0676-2
doi:

Substances chimiques

Anti-Bacterial Agents 0
Vancomycin 6Q205EH1VU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

735-745

Investigateurs

Vaclava Adamkova (V)
Timothy Barkham (T)
Karsten Becker (K)
Desiree Bennett (D)
Olivier Claris (O)
Clarence Buddy Creech (CB)
Herminia De Lencastre (H)
Margaret Deighton (M)
Olivier Denis (O)
John Ferguson (J)
Yhu-Chering Huang (YC)
Claus Klingenberg (C)
Andre Ingebretsen (A)
Celine Laferrière (C)
Katia Regina Netto Dos Santos (KRN)
Jacques Schrenzel (J)
Iris Spiliopoulou (I)
Stefania Stefani (S)
Kim TaekSoo (K)
Eveliina Tarkka (E)
Alex Friedrich (A)
Christina Vandenbroucke-Grauls (C)
James Ussher (J)
Francois Vandenesch (F)
Lars Westblade (L)
Jodi Lindsay (J)
Francois Vandenesch (F)
Anders Rhod Larsen (AR)
Philipp Zanger (P)
Barbara C Kahl (BC)
Cristina Prat Aymerich (CP)

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Auteurs

Thierry Wirth (T)

Institut Systématique Evolution Biodiversité (ISYEB), Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, Université des Antilles, EPHE, Paris, France. wirth@mnhn.fr.
PSL University, EPHE, Paris, France. wirth@mnhn.fr.

Marine Bergot (M)

Institut des Agents Infectieux, Département de Bactériologie, Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France.

Jean-Philippe Rasigade (JP)

Institut Systématique Evolution Biodiversité (ISYEB), Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, Université des Antilles, EPHE, Paris, France.
Institut des Agents Infectieux, Département de Bactériologie, Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France.
Centre International de recherche en Infectiologie, INSERM U1111 - CNRS UMR5308 - ENS Lyon - Université Lyon 1, Lyon, France.

Bruno Pichon (B)

Staphylococcus Reference Section, National Infection Service, Public Health England, London, UK.

Maxime Barbier (M)

Institut Systématique Evolution Biodiversité (ISYEB), Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, Université des Antilles, EPHE, Paris, France.

Patricia Martins-Simoes (P)

Institut des Agents Infectieux, Département de Bactériologie, Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France.
Centre International de recherche en Infectiologie, INSERM U1111 - CNRS UMR5308 - ENS Lyon - Université Lyon 1, Lyon, France.

Laurent Jacob (L)

Laboratoire Biométrie et Biologie Evolutive, CNRS UMR5558, Université Lyon 1, Lyon, France.

Rachel Pike (R)

Staphylococcus Reference Section, National Infection Service, Public Health England, London, UK.

Pierre Tissieres (P)

Institut de Biologie de la cellule (I2BC-UMR9198), CNRS, CEA, Univ. Paris Sud, Université Paris Saclay, Gif-sur-Yvette, France.
Service de Réanimation Néonatale, Hôpitaux Universitaires Paris Sud APHP, Le Kremlin-Bicêtre, Paris, France.

Jean-Charles Picaud (JC)

Service de Réanimation Néonatale, Hôpital Croix Rousse, Hospices Civils de Lyon, Lyon, France.

Angela Kearns (A)

Staphylococcus Reference Section, National Infection Service, Public Health England, London, UK.

Philip Supply (P)

Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France.

Marine Butin (M)

Centre International de recherche en Infectiologie, INSERM U1111 - CNRS UMR5308 - ENS Lyon - Université Lyon 1, Lyon, France. marine.butin@chu-lyon.fr.
Service de Réanimation Néonatale, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France. marine.butin@chu-lyon.fr.

Frédéric Laurent (F)

Institut des Agents Infectieux, Département de Bactériologie, Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France.
Centre International de recherche en Infectiologie, INSERM U1111 - CNRS UMR5308 - ENS Lyon - Université Lyon 1, Lyon, France.

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