Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis.
Adult
Anti-Bacterial Agents
/ pharmacology
Bayes Theorem
Drug Resistance, Multiple, Bacterial
/ drug effects
France
Genes, Bacterial
/ genetics
Genome, Bacterial
Genome-Wide Association Study
Genotype
Humans
Infant
Infant, Newborn
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Mutation
Neonatal Sepsis
/ microbiology
Phenotype
Polymorphism, Single Nucleotide
Recombination, Genetic
Staphylococcal Infections
/ microbiology
Staphylococcus capitis
/ drug effects
Vancomycin
/ therapeutic use
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
19
10
2019
accepted:
28
01
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
28
7
2020
Statut:
ppublish
Résumé
The multidrug-resistant Staphylococcus capitis NRCS-A clone is responsible for sepsis in preterm infants in neonatal intensive care units (NICUs) worldwide. Here, to retrace the spread of this clone and to identify drivers of its specific success, we investigated a representative collection of 250 S. capitis isolates from adults and newborns. Bayesian analyses confirmed the spread of the NRCS-A clone and enabled us to date its emergence in the late 1960s and its expansion during the 1980s, coinciding with the establishment of NICUs and the increasing use of vancomycin in these units, respectively. This dynamic was accompanied by the acquisition of mutations in antimicrobial resistance- and bacteriocin-encoding genes. Furthermore, combined statistical tools and a genome-wide association study convergently point to vancomycin resistance as a major driver of NRCS-A success. We also identified another S. capitis subclade (alpha clade) that emerged independently, showing parallel evolution towards NICU specialization and non-susceptibility to vancomycin, indicating convergent evolution in NICU-associated pathogens. These findings illustrate how the broad use of antibiotics can repeatedly lead initially commensal drug-susceptible bacteria to evolve into multidrug-resistant clones that are able to successfully spread worldwide and become pathogenic for highly vulnerable patients.
Identifiants
pubmed: 32341568
doi: 10.1038/s41564-020-0676-2
pii: 10.1038/s41564-020-0676-2
doi:
Substances chimiques
Anti-Bacterial Agents
0
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
735-745Investigateurs
Vaclava Adamkova
(V)
Timothy Barkham
(T)
Karsten Becker
(K)
Desiree Bennett
(D)
Olivier Claris
(O)
Clarence Buddy Creech
(CB)
Herminia De Lencastre
(H)
Margaret Deighton
(M)
Olivier Denis
(O)
John Ferguson
(J)
Yhu-Chering Huang
(YC)
Claus Klingenberg
(C)
Andre Ingebretsen
(A)
Celine Laferrière
(C)
Katia Regina Netto Dos Santos
(KRN)
Jacques Schrenzel
(J)
Iris Spiliopoulou
(I)
Stefania Stefani
(S)
Kim TaekSoo
(K)
Eveliina Tarkka
(E)
Alex Friedrich
(A)
Christina Vandenbroucke-Grauls
(C)
James Ussher
(J)
Francois Vandenesch
(F)
Lars Westblade
(L)
Jodi Lindsay
(J)
Francois Vandenesch
(F)
Anders Rhod Larsen
(AR)
Philipp Zanger
(P)
Barbara C Kahl
(BC)
Cristina Prat Aymerich
(CP)
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