Synthesis and biological evaluation of resveratrol derivatives with anti-breast cancer activity.
biological activity
breast cancer
resveratrol derivatives
structure-activity relationship
synthesis
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
17
02
2020
revised:
01
04
2020
accepted:
02
04
2020
pubmed:
29
4
2020
medline:
2
2
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
Resveratrol is a natural phytoestrogen produced by plants to protect themselves from injury, UV irradiation, and fungal attack. The main active structure is E-resveratrol, which has many pharmacological activities. As the structure of resveratrol is similar to the natural estrogen 17β-estradiol and the synthetic estrogen E-diethylstilbestrol, resveratrol is used in reducing the incidence of breast cancer. However, the therapeutic application of resveratrol is limited due to its low bioavailability. To improve its bioavailability and pharmacological activity, some resveratrol derivatives have been designed and synthesized by substitutions of methoxy, hydroxyl, and other functional groups or heterocyclic esterification either on the "A" or "B" ring, and double bonds were replaced by imine bonds and isometric heterocycles such as naphthyl and imidazole, or synthetic resveratrol oligomers. The structures, synthetic routes, and evaluation of the biological activities of these compounds are discussed. These are aimed at providing some references for the study of resveratrol derivatives in anti-breast cancer treatment.
Identifiants
pubmed: 32342549
doi: 10.1002/ardp.202000044
doi:
Substances chimiques
Antineoplastic Agents
0
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000044Informations de copyright
© 2020 Deutsche Pharmazeutische Gesellschaft.
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