Combination of CD47 and signal-regulatory protein-α constituting the "don't eat me signal" is a prognostic factor in diffuse large B-cell lymphoma.
Adult
Aged
Aged, 80 and over
Antigens, Differentiation
/ genetics
Antineoplastic Combined Chemotherapy Protocols
Biomarkers
CD47 Antigen
/ genetics
Cyclophosphamide
Doxorubicin
Female
Gene Expression
Humans
Immunohistochemistry
In Situ Hybridization
Lymphoma, Large B-Cell, Diffuse
/ metabolism
Middle Aged
Prednisone
Prognosis
Receptors, Immunologic
/ genetics
Rituximab
Signal Transduction
Treatment Outcome
Vincristine
hematology
immunohistochemistry
non-Hodgkin lymphoma
pathology
prognosis
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
12
2019
revised:
10
04
2020
accepted:
16
04
2020
pubmed:
29
4
2020
medline:
11
8
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
The interaction between CD47 and signal-regulatory protein-α (SIRPα) inhibits phagocytosis, thus affecting the clinical outcomes of neoplastic diseases. Although CD47 upregulation is associated with poor prognosis in several malignancies, the effect of SIRPα expression and its coexpression with CD47 remains unclear. This study aimed to investigate the clinicopathologic effect of CD47 and SIRPα expression in diffuse large B-cell lymphoma (DLBCL). Immunostaining of 120 biopsy samples showed that CD47 is primarily expressed in tumor cells, whereas SIRPα is expressed in nonneoplastic stromal cells, mostly macrophages. CD47
Identifiants
pubmed: 32342603
doi: 10.1111/cas.14437
pmc: PMC7385345
doi:
Substances chimiques
Antigens, Differentiation
0
Biomarkers
0
CD47 Antigen
0
CD47 protein, human
0
R-CHOP protocol
0
Receptors, Immunologic
0
SIRPA protein, human
0
Rituximab
4F4X42SYQ6
Vincristine
5J49Q6B70F
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Prednisone
VB0R961HZT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2608-2619Informations de copyright
© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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