Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.
adolescence
audiovisual integration
delta-beta coupling
neuronal oscillation
speech
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
10
10
2019
revised:
08
02
2020
accepted:
19
03
2020
pubmed:
29
4
2020
medline:
22
6
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
The ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase-amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high-frequency amplitude by low-frequency phase, is associated with audiovisual integration in adults. Thus, we investigated how PAC develops in adolescents and whether it is related to the functional maturation of audiovisual integration. In particular, we focused on the timing of PAC (or the coupling phase), which is defined as the low-frequency phase with maximum high-frequency amplitude. Using magnetoencephalography (MEG) on 15 adults and 14 adolescents while they performed an audiovisual speech integration task, we examined PAC in association cortexes with a trial-by-trial analysis. Whereas delta-beta coupling was consistently observed in both adults and adolescents, we found that the timing of delta-beta PAC was delayed by 20-40 milliseconds in adolescents compared with adults. In addition, a logistic regression analysis revealed that the task performance improves as the timing of delta-beta PAC in the right temporal pole (TP) got closer to the trough position (180 degrees). These results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents.
Identifiants
pubmed: 32342667
doi: 10.1002/brb3.1635
pmc: PMC7303405
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01635Subventions
Organisme : Japan Science Society
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 15H04890
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 16H06397
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 16K19748
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 17H06581
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 19K16891
Pays : International
Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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