Phase-Separated Multienzyme Biosynthesis.

Biocatalysis Multienzyme Complexes / genetics Phase Transition Proteins / metabolism

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
08 06 2020
Historique:
pubmed: 29 4 2020
medline: 22 6 2021
entrez: 29 4 2020
Statut: ppublish

Résumé

Liquid-liquid phase separation forms condensates that feature a highly concentrated liquid phase, a defined yet dynamic boundary, and dynamic exchange at and across the boundary. Phase transition drives the formation of dynamic multienzyme complexes in cells, for example, the purinosome, which forms subcellular macrobodies responsible for

Identifiants

DOI: 10.1021/acs.biomac.0c00321 PMID: 32343131
pubmed: 32343131
doi: 10.1021/acs.biomac.0c00321
doi:

Substances chimiques

Multienzyme Complexes 0
Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2391-2399

Auteurs

Miao Liu (M)

Department of Chemistry, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Sicong He (S)

Department of Electronic and Computer Engineering, Center of Systems Biology and Human Health, School of Science and Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.

Lixin Cheng (L)

Department of Critical Care Medicine, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518000, China.

Jianan Qu (J)

Department of Electronic and Computer Engineering, Center of Systems Biology and Human Health, School of Science and Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
ORCID: 0000-0002-6809-0087

Jiang Xia (J)

Department of Chemistry, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Center for Cell & Developmental Biology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 02522, China.
ORCID: 0000-0001-8112-7625

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Biocatalyse › Phase-Separated Multienzyme Biosynthesis.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Phase-Separated Multienzyme Biosynthesis.
questionsmedicales.fr › Phénomènes chimiques › Transition de phase › Phase-Separated Multienzyme Biosynthesis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phase-Separated Multienzyme Biosynthesis.