Gene Prioritization in Parkinson's Disease Using Human Protein-Protein Interaction Network.

Parkinson's disease (PD) is the second-most common neurodegenerative disorder, and the actual cause of this disease is still unknown. Identifying the target genes that are associated with disease plays an essential role in the treatment of PD. Various genetic studies have determined the significant target genes for disease progression, although this continues to be challenging in the field of drug designing. In this study, we proposed a network-based approach to identify target genes for PD using gene mutation, gene expression, and gene deletion analysis. The subnetwork of PD genes was constructed from human protein-protein interaction network, and the potential genes were identified using network centrality measures. Two genes,