Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.

Cell Transformation, Neoplastic / genetics Cytogenetic Analysis Disease Progression Gene Expression Regulation, Leukemic Humans Leukemia, Myelomonocytic, Chronic / genetics Mutation Neoplasm Staging Neoplastic Stem Cells / metabolism Prognosis Retrospective Studies Signal Transduction ras Proteins / genetics
AML CFU-GM CMML RAS-pathway mutations

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Apr 2020
Historique:
received: 05 04 2020
revised: 19 04 2020
accepted: 22 04 2020
entrez: 30 4 2020
pubmed: 30 4 2020
medline: 2 2 2021
Statut: epublish

Résumé

Although the RAS-pathway has been implicated as an important driver in the pathogenesis of chronic myelomonocytic leukemia (CMML) a comprehensive study including molecular and functional analyses in patients with progression and transformation has not been performed. A close correlation between RASopathy gene mutations and spontaneous in vitro myeloid colony (CFU-GM) growth in CMML has been described. Molecular and/or functional analyses were performed in three cohorts of 337 CMML patients: in patients without (A,

Identifiants

DOI: 10.3390/ijms21083025 PMID: 32344757 PMC: PMC7215883
pubmed: 32344757
pii: ijms21083025
doi: 10.3390/ijms21083025
pmc: PMC7215883
pii:
doi:

Substances chimiques

ras Proteins EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund
ID : F4704-B20
Organisme : CSRD VA
ID : 1
Pays : United States

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Auteurs

Klaus Geissler (K)

Medical School, Sigmund Freud University, 1020 Vienna, Austria.
Department of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.

Eva Jäger (E)

Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Agnes Barna (A)

Blood Transfusion Service, Blood Transfusion Service for Upper Austria, Austrian Red Cross, 4020 Linz, Austria.

Michael Gurbisz (M)

Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Temeida Graf (T)

Department of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.

Elmir Graf (E)

Department of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.

Thomas Nösslinger (T)

Department of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.

Michael Pfeilstöcker (M)

Department of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.

Heinz Tüchler (H)

Department of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.

Thamer Sliwa (T)

Department of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.

Felix Keil (F)

Department of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.

Christoph Geissler (C)

Department of Laboratory Medicine, Hospital Hietzing, 1130 Vienna, Austria.

Sonja Heibl (S)

Department of Internal Medicine IV, Hospital Wels-Grieskirchen, 4600 Wels, Austria.

Josef Thaler (J)

Department of Internal Medicine IV, Hospital Wels-Grieskirchen, 4600 Wels, Austria.

Sigrid Machherndl-Spandl (S)

Department of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.

Otto Zach (O)

Department of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.
ORCID: 0000-0002-1754-6849

Ansgar Weltermann (A)

Department of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.

Peter Bettelheim (P)

Department of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern - Elisabethinen, 4020 Linz, Austria.

Reinhard Stauder (R)

Internal Medicine V with Hematology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
ORCID: 0000-0002-8993-9561

Armin Zebisch (A)

Department of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.
Otto-Loewi-Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, 8036 Graz, Austria.
ORCID: 0000-0002-4861-7021

Heinz Sill (H)

Department of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.
ORCID: 0000-0003-0993-4371

Ilse Schwarzinger (I)

Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Bruno Schneeweiss (B)

Department of Internal Medicine, Hospital Kirchdorf, 4560 Kirchdorf, Austria.

Leopold Öhler (L)

Department of Internal Medicine/Oncology, St. Josef Hospital, 1130 Vienna, Austria.

Ernst Ulsperger (E)

Department of Internal Medicine, Hospital Horn, 3580 Horn, Austria.

Rajko Kusec (R)

School of Medicine, University of Zagreb, University Hospital Dubrava, 10000 Zagreb, Croatia.

Ulrich Germing (U)

Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, 40225 Düsseldorf, Germany.

Wolfgang R Sperr (WR)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.

Paul Knöbl (P)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.

Ulrich Jäger (U)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
ORCID: 0000-0001-9826-1062

Gregor Hörmann (G)

Central Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Peter Valent (P)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Ludwig Boltzmann Institute for Hematology and Oncology (LBI HO), Medical University of Vienna, 1090 Vienna, Austria.
ORCID: 0000-0003-0456-5095

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse cytogénétique › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Régulation de l'expression des gènes dans la leucémie › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie myélomonocytaire chronique › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Diagnostic › Pronostic › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Correlation of RAS-Pathway Mutations and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G ras › Correlation of RAS-Pathway Mutations and...