Increased Protein
Adenosine Triphosphate
/ metabolism
Adult
Aged
Disease Susceptibility
Electron Transport Complex I
/ metabolism
Female
Fibroblasts
/ drug effects
Humans
Male
Middle Aged
Mitochondria
/ metabolism
Models, Molecular
Optic Atrophy, Hereditary, Leber
/ drug therapy
Protein Conformation
Protein Processing, Post-Translational
Protein S
/ chemistry
Proteome
Proteomics
/ methods
Reactive Oxygen Species
/ metabolism
Signal Transduction
Structure-Activity Relationship
Young Adult
LHON
Leber’s Hereditary Optic Neuropathy
S-glutathionylation
mitochondrial Complex I
proteomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Apr 2020
24 Apr 2020
Historique:
received:
10
03
2020
revised:
11
04
2020
accepted:
22
04
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Leber's hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA-related diseases. The pathogenicity of mutations in genes encoding components of mitochondrial Complex I is well established, but the underlying pathomechanisms of the disease are still unclear. Hypothesizing that oxidative stress related to Complex I deficiency may increase protein
Identifiants
pubmed: 32344771
pii: ijms21083027
doi: 10.3390/ijms21083027
pmc: PMC7215361
pii:
doi:
Substances chimiques
Protein S
0
Proteome
0
Reactive Oxygen Species
0
Adenosine Triphosphate
8L70Q75FXE
Electron Transport Complex I
EC 7.1.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Medical Research Council
ID : CG 2013 and CG 2017
Organisme : SingHealth Foundation
ID : Proteomics core facility
Références
J Comput Chem. 2005 Dec;26(16):1701-18
pubmed: 16211538
Mol Cell Proteomics. 2018 Oct;17(10):2034-2050
pubmed: 30006487
Antioxid Redox Signal. 2012 Mar 15;16(6):476-95
pubmed: 21954972
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
BMC Res Notes. 2011 Dec 22;4:557
pubmed: 22192149
Mitochondrion. 2006 Aug;6(4):161-75
pubmed: 16815102
Nature. 2010 Oct 21;467(7318):929-34
pubmed: 20962839
J Biol Chem. 2013 Sep 13;288(37):26497-504
pubmed: 23861399
PLoS One. 2009 Nov 19;4(11):e7922
pubmed: 19936068
Biochim Biophys Acta. 2013 May;1830(5):3165-72
pubmed: 23416063
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
PLoS One. 2014 Sep 12;9(9):e106779
pubmed: 25215595
Hum Mol Genet. 2017 Aug 1;26(R1):R12-R20
pubmed: 28481993
J Biol Chem. 2009 Jun 12;284(24):16236-45
pubmed: 19366681
Annu Rev Genomics Hum Genet. 2008;9:87-107
pubmed: 18767960
Hum Mol Genet. 2017 Oct 1;26(R2):R139-R150
pubmed: 28977448
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9598-603
pubmed: 18621725
Int J Mol Sci. 2013 Oct 17;14(10):20845-76
pubmed: 24141185
Biochim Biophys Acta. 2008 Oct;1783(10):1707-17
pubmed: 18513491
EBioMedicine. 2018 Apr;30:29-37
pubmed: 29605508
Curr Treat Options Neurol. 2011 Feb;13(1):109-17
pubmed: 21063922
J Phys Chem B. 2012 Mar 15;116(10):3164-79
pubmed: 22352995
Ann Neurol. 2008 Jun;63(6):794-8
pubmed: 18496845
Curr Opin Neurol. 2010 Feb;23(1):24-8
pubmed: 19915464
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494
pubmed: 29762782
J Neurosci Res. 2008 Nov 15;86(15):3331-7
pubmed: 18615737
J Biol Chem. 2009 Jan 2;284(1):436-45
pubmed: 18990698
Biochem J. 2004 Jun 15;380(Pt 3):919-28
pubmed: 15018610
Cells. 2018 Dec 17;7(12):
pubmed: 30563029
FASEB J. 2003 Sep;17(12):1706-8
pubmed: 12958183
Chem Biol Interact. 2019 Feb 1;299:151-162
pubmed: 30537466
FEBS Lett. 1996 Apr 8;384(1):53-7
pubmed: 8797802
Curr Opin Neurol. 2019 Feb;32(1):99-104
pubmed: 30516647
Eur J Ophthalmol. 2012 May-Jun;22(3):461-5
pubmed: 21928272
Trends Mol Med. 2017 Aug;23(8):693-708
pubmed: 28716624
Brain. 2014 Feb;137(Pt 2):335-53
pubmed: 24369379
Biochim Biophys Acta. 2011 Jun;1807(6):562-7
pubmed: 20950584
Antioxid Redox Signal. 2012 Mar 15;16(6):524-42
pubmed: 22010840
Brain. 2016 Nov 1;139(11):2864-2876
pubmed: 27633772