Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets.
Aging
/ drug effects
Amyloid beta-Peptides
/ antagonists & inhibitors
Animals
Brain
/ drug effects
Clinical Trials as Topic
/ methods
Drug Delivery Systems
/ methods
Gene-Environment Interaction
Humans
Immunologic Factors
/ administration & dosage
Immunotherapy
/ methods
Neurodegenerative Diseases
/ drug therapy
alpha-Synuclein
/ antagonists & inhibitors
tau Proteins
/ antagonists & inhibitors
Alzheimer’s disease
Aβ
Immunotherapy
tau
vaccination
α-synuclein
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
30
4
2020
medline:
2
9
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
Neurological disorders such as Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying treatments to date and now constitute a dementia crisis that affects 5 million in the USA and over 50 million worldwide. The most common pathological hallmark of these age-related neurodegenerative diseases is the accumulation of specific proteins, including amyloid beta (Aβ), tau, α-synuclein (α-syn), TAR DNA-binding protein 43 (TDP43), and repeat-associated non-ATG (RAN) peptides, in the intra- and extracellular spaces of selected brain regions. Whereas it remains controversial whether these accumulations are pathogenic or merely a byproduct of disease, the majority of therapeutic research has focused on clearing protein aggregates. Immunotherapies have garnered particular attention for their ability to target specific protein strains and conformations as well as promote clearance. Immunotherapies can also be neuroprotective: by neutralizing extracellular protein aggregates, they reduce spread, synaptic damage, and neuroinflammation. This review will briefly examine the current state of research in immunotherapies against the 3 most commonly targeted proteins for age-related neurodegenerative disease: Aβ, tau, and α-syn. The discussion will then turn to combinatorial strategies that enhance the effects of immunotherapy against aggregating protein, followed by new potential targets of immunotherapy such as aging-related processes.
Identifiants
pubmed: 32347461
doi: 10.1007/s13311-020-00853-2
pii: 10.1007/s13311-020-00853-2
pmc: PMC7222955
doi:
Substances chimiques
Amyloid beta-Peptides
0
Immunologic Factors
0
alpha-Synuclein
0
tau Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
935-954Références
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