Reproducible Quantification of Regional Sympathetic Denervation with [
PET
cardiac innervation
innervation tracers
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
12
12
2019
accepted:
13
03
2020
pubmed:
30
4
2020
medline:
25
3
2022
entrez:
30
4
2020
Statut:
ppublish
Résumé
Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between automated software programs has not been evaluated. This study seeks to (1) compare the inter-rater reliability of regional denervation measurements using two analysis programs: FlowQuant N = 190 dynamic [ Inter-observer, inter-software, and test-retest ICC values were excellent (ICC = 94% to 99%) and measurement variability was small (RPC < 11%). Mean differences between observers ranged .2% to 1.1% for Corridor4DM (P = .28), FlowQuant (P < .001), and between software programs (P < .001). Kaplan-Meier analysis demonstrated HED scores from both programs were predictive of SCA. Inter-rater reliability for both analysis programs was excellent and test-retest repeatability was consistent. The minimal difference in scores between FlowQuant and Corridor4DM supports their use in future trials.
Sections du résumé
BACKGROUND
Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between automated software programs has not been evaluated. This study seeks to (1) compare the inter-rater reliability of regional denervation measurements using two analysis programs: FlowQuant
METHODS
N = 190 dynamic [
RESULTS
Inter-observer, inter-software, and test-retest ICC values were excellent (ICC = 94% to 99%) and measurement variability was small (RPC < 11%). Mean differences between observers ranged .2% to 1.1% for Corridor4DM (P = .28), FlowQuant (P < .001), and between software programs (P < .001). Kaplan-Meier analysis demonstrated HED scores from both programs were predictive of SCA.
CONCLUSION
Inter-rater reliability for both analysis programs was excellent and test-retest repeatability was consistent. The minimal difference in scores between FlowQuant and Corridor4DM supports their use in future trials.
Identifiants
pubmed: 32347526
doi: 10.1007/s12350-020-02114-3
pii: 10.1007/s12350-020-02114-3
pmc: PMC7673573
mid: NIHMS1631611
doi:
Substances chimiques
Contrast Media
0
3-hydroxyephedrine
3002-40-2
Ephedrine
GN83C131XS
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2745-2757Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL130266
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001412
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2020. American Society of Nuclear Cardiology.
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