Drugs during cardiopulmonary resuscitation.
Journal
Current opinion in critical care
ISSN: 1531-7072
Titre abrégé: Curr Opin Crit Care
Pays: United States
ID NLM: 9504454
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
1
12
2020
Statut:
ppublish
Résumé
The current narrative review outlines the evidence for the most common drugs given during adult cardiopulmonary resuscitation. Two large clinical trials recently made the roles of adrenaline and antiarrhythmic drugs clearer. Adrenaline leads to a substantially higher rate of return of spontaneous circulation and a moderate increase in survival. Amiodarone and lidocaine increase short-term outcomes, and point estimates suggest a small but uncertain effect on long-term survival. There is still a lack of high-quality evidence for other drugs during cardiac arrest such as bicarbonate, calcium, and magnesium, but small-scale randomized clinical trials show no effect. A promising entity may be the combination of vasopressin and glucocorticoids, but external validation of preliminary trials is needed. Data from observational studies and subgroup analyses of trials generally favor intravenous over intraosseous access, while the latter remains a reasonable alternative. Guidelines for the above-mentioned drugs have been updated yet remain largely unchanged over the last decades. There are still multiple unanswered questions related to drugs during cardiopulmonary resuscitation. On the contrary, only few trials are ongoing.
Identifiants
pubmed: 32348092
doi: 10.1097/MCC.0000000000000718
pii: 00075198-202006000-00005
doi:
Substances chimiques
Anti-Arrhythmia Agents
0
Amiodarone
N3RQ532IUT
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
242-250Références
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