MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury.
BBB disruption
Hypoxic ischemia encephalopathy (HIE)
MMP
ischemic stroke
miRNA
neural
inflammation
tight junction
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
03
2020
revised:
31
03
2020
accepted:
24
04
2020
pubmed:
30
4
2020
medline:
26
11
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
Hypoxic-ischemic (HI) brain injury is a leading cause of acute mortality and chronic disability in newborns. Current evidence shows that cerebral microvascular response and compromised blood-brain barrier (BBB) integrity occur rapidly and could primarily be responsible for the brain injury observed in many infants with HI brain injury. MicroRNAs (miRNAs) are a type of highly conserved non-coding RNAs (ncRNAs), which consist of 21-25 nucleotides in length and usually lead to suppression of target gene expression. Growing evidence has revealed that brainenriched miRNAs act as versatile regulators of BBB dysfunctions in various neurological disorders including neonatal HI brain injury. In the present review, we summarize the current findings regarding the role of miRNAs in BBB impairment after hypoxia/ischemia brain injury. Specifically, we focus on the recent progress of miRNAs in the pathologies of neonatal HI brain injury. These findings can not only deepen our understanding of the role of miRNAs in BBB impairment in HI brain injury, but also provide insight into the development of new therapeutic strategies for preservation of BBB integrity under pathological conditions.
Identifiants
pubmed: 32348227
pii: CN-EPUB-106204
doi: 10.2174/1570159X18666200429004242
pmc: PMC7770646
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1180-1186Subventions
Organisme : NINDS NIH HHS
ID : R01 NS112404
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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