Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1β-induced Primary Human Articular Chondrocytes.
Anti-Inflammatory Agents
/ pharmacology
Apoptosis
/ drug effects
Arachidonate 5-Lipoxygenase
/ metabolism
Boswellia
/ chemistry
Cell Survival
/ drug effects
Cells, Cultured
Chondrocytes
/ drug effects
Curcuma
/ chemistry
Cyclooxygenase 2
/ metabolism
Cyclooxygenase 2 Inhibitors
/ pharmacology
Cytokines
/ metabolism
Humans
Inflammation
/ drug therapy
Interleukin-1beta
/ metabolism
Leukotriene B4
/ metabolism
Lipoxygenase Inhibitors
/ pharmacology
MAP Kinase Signaling System
/ drug effects
Metalloproteases
/ metabolism
NF-kappa B
/ metabolism
Osteoarthritis
/ drug therapy
Plant Extracts
/ pharmacology
Prostaglandin-E Synthases
/ metabolism
Receptors, Prostaglandin E
/ metabolism
Rhizome
/ chemistry
Terminalia
/ chemistry
Boswellia serrata extracts
Curcuma longa rhizome extracts
LI73014F2
Terminalia chebula fruit extracts
anti-inflammation
apoptosis
human articular chondrocyte
interleukin-1β
metalloproteinases
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Apr 2020
27 Apr 2020
Historique:
received:
10
03
2020
revised:
16
04
2020
accepted:
25
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Osteoarthritis (OA) is one of the most well-characterized joint diseases and is associated with chondrocyte inflammation, metalloproteinase upregulation and apoptosis. LI73014F2 is a novel composition prepared from aqueous extract of
Identifiants
pubmed: 32349389
pii: molecules25092033
doi: 10.3390/molecules25092033
pmc: PMC7249004
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cyclooxygenase 2 Inhibitors
0
Cytokines
0
IL1B protein, human
0
Interleukin-1beta
0
Lipoxygenase Inhibitors
0
NF-kappa B
0
Plant Extracts
0
Receptors, Prostaglandin E
0
Leukotriene B4
1HGW4DR56D
turmeric extract
856YO1Z64F
Arachidonate 5-Lipoxygenase
EC 1.13.11.34
Cyclooxygenase 2
EC 1.14.99.1
ALOX5 protein, human
EC 1.3.11.34
Metalloproteases
EC 3.4.-
PTGES protein, human
EC 5.3.99.3
Prostaglandin-E Synthases
EC 5.3.99.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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