sLRP1 (Soluble Low-Density Lipoprotein Receptor-Related Protein 1): A Novel Biomarker for P2Y12 (P2Y Purinoceptor 12) Receptor Expression in Atherosclerotic Plaques.

Actins / analysis Animals Apolipoproteins E / deficiency Biomarkers / analysis Clopidogrel / pharmacology Cyclic AMP / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Diet, High-Fat Gene Expression Gene Knockdown Techniques Low Density Lipoprotein Receptor-Related Protein-1 / analysis Male Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular / chemistry Plaque, Atherosclerotic / chemistry Purinergic P2Y Receptor Antagonists / pharmacology Receptors, Purinergic P2Y12 / drug effects Signal Transduction Sterol Regulatory Element Binding Protein 2 / metabolism
atherosclerosis biomarker clopidogrel high-fat diet vascular smooth muscle cell

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
06 2020
Historique:
pubmed: 1 5 2020
medline: 14 7 2020
entrez: 1 5 2020
Statut: ppublish

Résumé

Recent studies suggest that the P2Y12 (P2Y purinoceptor 12) receptor of vascular smooth muscle cells in atherosclerotic plaques aggravates atherosclerosis, and P2Y12 receptor inhibitors such as CDL (clopidogrel) may effectively treat atherosclerosis. It is imperative to identify an effective biomarker for reflecting the P2Y12 receptor expression on vascular smooth muscle cells in plaques. Approach and Results: We found that there was a positive correlation between the level of circulating sLRP1 (soluble low-density lipoprotein receptor-related protein 1) and the number of LRP1 Our study suggests that sLRP1 may be a biomarker that reflects the P2Y12 receptor level in plaques and has the potential to be an indicator for administering P2Y12 receptor inhibitors for patients with atherosclerosis.

Identifiants

DOI: 10.1161/ATVBAHA.120.314350 PMID: 32349534
pubmed: 32349534
doi: 10.1161/ATVBAHA.120.314350
doi:

Substances chimiques

Actins 0
Apolipoproteins E 0
Biomarkers 0
Low Density Lipoprotein Receptor-Related Protein-1 0
P2ry12 protein, mouse 0
Purinergic P2Y Receptor Antagonists 0
Receptors, Purinergic P2Y12 0
Srebf2 protein, mouse 0
Sterol Regulatory Element Binding Protein 2 0
alpha-smooth muscle actin, mouse 0
Clopidogrel A74586SNO7
Cyclic AMP E0399OZS9N
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e166-e179

Auteurs

Jiefang Chen (J)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Shulan Pi (S)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cheng Yu (C)

Department of Ultrasound (C.Y.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hanqing Shi (H)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yuxiao Liu (Y)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xiaoqing Guo (X)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Lian Zhou (L)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yuanyuan Li (Y)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hui He (H)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yuanpeng Xia (Y)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Ling Mao (L)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Bo Hu (B)

From the Department of Neurology (J.C., S.P., H.S., Y. Liu, X.G., L.Z., Y. Li, H.H., Y.X., L.M., B.H.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Eucaryotes › Animaux › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Thiénopyridines › Ticlopidine › Clopidogrel › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Protéines apparentées au récepteur LDL › Protéine-1 apparentée au récepteur des LDL › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P2 › Antagonistes des récepteurs purinergiques P2Y › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Récepteurs purinergiques P2Y12 › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › sLRP1 (Soluble Low-Density Lipoprotein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-2 de liaison à l'élément de régulation des stérols › sLRP1 (Soluble Low-Density Lipoprotein...