MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
Animals
Behavior, Animal
Caenorhabditis elegans
/ drug effects
Caenorhabditis elegans Proteins
/ metabolism
Gene Expression Regulation
/ drug effects
Green Fluorescent Proteins
/ metabolism
Immunity
/ drug effects
Interleukin-17
/ metabolism
Interneurons
/ drug effects
Longevity
/ drug effects
Models, Biological
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
/ metabolism
Neurons
/ drug effects
Oxygen
/ pharmacology
Signal Transduction
/ drug effects
Subcellular Fractions
/ metabolism
Transgenes
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 04 2020
29 04 2020
Historique:
received:
22
05
2019
accepted:
26
03
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
30
7
2020
Statut:
epublish
Résumé
Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans neurons. We identify the paracaspase MALT-1 as a critical output of the pathway. MALT1 mediates signaling from many immune receptors in mammals, but was not previously implicated in IL-17 signaling or nervous system function. C. elegans MALT-1 forms a complex with homologs of Act1 and IRAK and appears to function both as a scaffold and a protease. MALT-1 is expressed broadly in the C. elegans nervous system, and neuronal IL-17-MALT-1 signaling regulates multiple phenotypes, including escape behavior, associative learning, immunity and longevity. Our data suggest MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior.
Identifiants
pubmed: 32350248
doi: 10.1038/s41467-020-15872-y
pii: 10.1038/s41467-020-15872-y
pmc: PMC7190641
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Interleukin-17
0
Green Fluorescent Proteins
147336-22-9
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
EC 3.4.22.-
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2099Subventions
Organisme : Medical Research Council
ID : MC_U105178786
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209504/Z/17/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
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