The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis.
Adrenergic hyperactivity
Arterial hypertension
Autonomic nervous system
Comorbidities
Multiple sclerosis
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
18
11
2019
accepted:
16
04
2020
pubmed:
1
5
2020
medline:
15
5
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS). The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels. Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24, p = 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (r This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.
Identifiants
pubmed: 32350673
doi: 10.1007/s10072-020-04432-3
pii: 10.1007/s10072-020-04432-3
doi:
Substances chimiques
Adrenergic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3157-3164Subventions
Organisme : Hrvatska Zaklada za Znanost
ID : 2622
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