Crypt residing bacteria and proximal colonic carcinogenesis in a mouse model of Lynch syndrome.
Animals
Bacteria
/ pathogenicity
Biofilms
/ growth & development
Carcinogenesis
/ genetics
Cell Transformation, Neoplastic
/ genetics
Colorectal Neoplasms
/ genetics
Colorectal Neoplasms, Hereditary Nonpolyposis
/ genetics
DNA Mismatch Repair
/ genetics
Disease Models, Animal
Dysbiosis
/ genetics
Gastrointestinal Microbiome
/ genetics
Germ-Line Mutation
/ genetics
Inflammation
/ genetics
Interleukin-10
/ genetics
Intestinal Mucosa
/ microbiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Lynch syndrome
colorectal cancer
inflammatory bowel disease
microbiota
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
received:
22
11
2019
revised:
11
03
2020
accepted:
14
04
2020
pubmed:
1
5
2020
medline:
13
4
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
Colorectal cancer is a multifactorial disease involving inherited DNA mutations, environmental factors, gut inflammation and intestinal microbiota. Certain germline mutations within the DNA mismatch repair system are associated with Lynch syndrome tumors including right-sided colorectal cancer with mucinous phenotype and presence of an inflammatory infiltrate. Such tumors are more often associated with bacterial biofilms, which may contribute to disease onset and progression. Inflammatory bowel diseases are also associated with colorectal cancer and intestinal dysbiosis. Herein we addressed the question, whether inflammation can aggravate colorectal cancer development under mismatch repair deficiency. MSH2
Identifiants
pubmed: 32350866
doi: 10.1002/ijc.33028
pmc: PMC7496850
doi:
Substances chimiques
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2316-2326Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 557
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : I 1573-B19
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P27831-B28
Pays : Austria
Organisme : European Research Council
ID : 741623
Pays : International
Organisme : Austrian Science Fund FWF
ID : KLI 557-B22
Pays : Austria
Informations de copyright
© 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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