A phase 2 multicenter study of ublituximab, a novel glycoengineered anti-CD20 monoclonal antibody, in patients with relapsing forms of multiple sclerosis.


Journal

Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185

Informations de publication

Date de publication:
03 2021
Historique:
pubmed: 1 5 2020
medline: 25 9 2021
entrez: 1 5 2020
Statut: ppublish

Résumé

Ublituximab, a novel monoclonal antibody (mAb) targeting a unique epitope on the CD20 antigen, is glycoengineered for enhanced B-cell targeting through antibody-dependent cellular cytotoxicity (ADCC). Greater ADCC may allow lower doses and shorter infusion times versus other anti-CD20 mAbs. The objective was to determine optimal dose, infusion time, and activity of ublituximab in relapsing multiple sclerosis. This is a phase 2, placebo-controlled study. Patients received three ublituximab infusions (150 mg over 1-4 hours on day 1 and 450-600 mg over 1-3 hours on day 15 and week 24) in six dosing cohorts. The primary endpoint was B-cell depletion. In all cohorts ( Ublituximab was safely infused as rapid as 1 hour, producing robust B-cell depletion and profound reductions in magnetic resonance imaging (MRI) activity and relapses.

Sections du résumé

BACKGROUND
Ublituximab, a novel monoclonal antibody (mAb) targeting a unique epitope on the CD20 antigen, is glycoengineered for enhanced B-cell targeting through antibody-dependent cellular cytotoxicity (ADCC). Greater ADCC may allow lower doses and shorter infusion times versus other anti-CD20 mAbs.
OBJECTIVE
The objective was to determine optimal dose, infusion time, and activity of ublituximab in relapsing multiple sclerosis.
METHODS
This is a phase 2, placebo-controlled study. Patients received three ublituximab infusions (150 mg over 1-4 hours on day 1 and 450-600 mg over 1-3 hours on day 15 and week 24) in six dosing cohorts. The primary endpoint was B-cell depletion.
RESULTS
In all cohorts (
CONCLUSION
Ublituximab was safely infused as rapid as 1 hour, producing robust B-cell depletion and profound reductions in magnetic resonance imaging (MRI) activity and relapses.

Identifiants

pubmed: 32351164
doi: 10.1177/1352458520918375
pmc: PMC7897779
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antigens, CD20 0
ublituximab U59UGK3IPC

Types de publication

Clinical Trial, Phase II Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

420-429

Références

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Auteurs

Edward Fox (E)

Central Texas Neurology Consultants, Round Rock, TX, USA.

Amy E Lovett-Racke (AE)

Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Matthew Gormley (M)

Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Yue Liu (Y)

Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Maria Petracca (M)

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Sirio Cocozza (S)

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.

Richard Shubin (R)

SC3 Research Group, Inc., Pasadena, CA, USA.

Sibyl Wray (S)

Hope Neurology Multiple Sclerosis Center, Knoxville, TN, USA.

Michael S Weiss (MS)

TG Therapeutics, Inc., New York, NY, USA.

Jenna A Bosco (JA)

TG Therapeutics, Inc., New York, NY, USA.

Sean A Power (SA)

TG Therapeutics, Inc., New York, NY, USA.

Koby Mok (K)

TG Therapeutics, Inc., New York, NY, USA.

Matilde Inglese (M)

Medical Center, Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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Classifications MeSH